Evidence map›Paper›PMID 35046823›Full record

ArticleFrontiers in pharmacology2021

Proanthocyanidins Protect Against Cadmium-Induced Diabetic Nephropathy Through p38 MAPK and Keap1/Nrf2 Signaling Pathways.

Pin Gong, Peipei Wang, Sihui Pi, Yuxi Guo, Shuya Pei, Wenjuan Yang, Xiangna Chang, Lan Wang, Fuxin Chen

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. NRF2 Dysregulation and Therapeutic Insights Across Chronic Kidney Diseases.International journal of molecular sciences · 2025
    Review
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  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Protective Effect ofMolecules (Basel, Switzerland) · 2023
    Article
  13. Review
  14. Review
  15. Article
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  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pin GongCollege of Food and Biotechnology, Shaanxi University of Science and Technology, Xi'an, China.
Peipei WangCollege of Food and Biotechnology, Shaanxi University of Science and Technology, Xi'an, China.
Sihui PiCollege of Food and Biotechnology, Shaanxi University of Science and Technology, Xi'an, China.
Yuxi GuoCollege of Food and Biotechnology, Shaanxi University of Science and Technology, Xi'an, China.
Shuya PeiCollege of Food and Biotechnology, Shaanxi University of Science and Technology, Xi'an, China.
Wenjuan YangCollege of Food and Biotechnology, Shaanxi University of Science and Technology, Xi'an, China.
Xiangna ChangCollege of Food and Biotechnology, Shaanxi University of Science and Technology, Xi'an, China.
Lan WangCollege of Food and Biotechnology, Shaanxi University of Science and Technology, Xi'an, China.
Fuxin ChenSchool of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, Xi'an, China.
Shaanxi University of Science and Technology · CNXi'an University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is one of the most devastating complications of diabetes mellitus. Although cadmium (Cd) exposure might be involved in the pathogenesis of DN, the underlying mechanism is still unclear. In this study, we explored the protective effects and possible mechanism of proanthocyanidins (OPC) from grape seed using a mouse model of Cd-induced DN. The successful establishment of this model was verified by analyzing the physiological and biochemical indices of mice, including their body weight and tissue ratio; levels of blood glucose, creatinine, microalbumin, total cholesterol, triglycerides, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol; and was based on histopathological examination. Oxidative-antioxidative status, elemental analysis, and key signaling pathway analysis were performed to explore the possible protective mechanism of OPC. The protective effects of OPC and its possible mechanism in preventing the progression of DN were investigated using a multidimensional approach, including its ability in regulating oxidative-antioxidative status (lipid peroxidation, protein carbonyl, superoxide dismutase, and glutathione GST, GSH-Px), metal-binding ability (Cd levels in the kidneys and urine and MT content) and mediation of essential elements (Zn, Ca, Cu, and Fe levels in the kidneys), and activation of the p38 MAPK and Keap1/Nrf2 signaling pathways. OPC exhibited a significant renoprotective effect, attributed to the metal-chelating ability, anti-oxidative effect, and mediation of oxidative stress-related signaling pathway. These results highlight the potential of OPC in preventing or treating DN in humans and suggest the dietary intake of grapes, which are rich in polyphenols, for the prevention of type 2 diabetes mellitus and its complications.

Indexed as

cadmiumdiabetic nephropathyKeap1/Nrf2 signaling pathwayp38 MAPK signaling pathwayproanthocyanidins

Identifiers

PMID35046823
PMCPMC8762225
OpenAlexW4205353220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.