ReviewFrontiers in synaptic neuroscience2021
(M)Unc13s in Active Zone Diversity: A
Review in Frontiers in synaptic neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Mitochondrial ROS modulate presynaptic plasticity in the drosophila neuromuscular junction.Redox biology · 2025Article
- Article
- Synapse Dysfunctions in Multiple Sclerosis.International journal of molecular sciences · 2023Review
- SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023Article
- A brain-wide form of presynaptic active zone plasticity orchestrates resilience to brain aging in Drosophila.PLoS biology · 2022Article
- Endogenous tagging of Unc-13 reveals nanoscale reorganization at active zones during presynaptic homeostatic potentiation.Frontiers in cellular neuroscience · 2022Article
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Authors and funding
2 authors.
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Abstract
The so-called active zones at pre-synaptic terminals are the ultimate filtering devices, which couple between action potential frequency and shape, and the information transferred to the post-synaptic neurons, finally tuning behaviors. Within active zones, the release of the synaptic vesicle operates from specialized "release sites." The (M)Unc13 class of proteins is meant to define release sites topologically and biochemically, and diversity between Unc13-type release factor isoforms is suspected to steer diversity at active zones. The two major Unc13-type isoforms, namely, Unc13A and Unc13B, have recently been described from the molecular to the behavioral level, exploiting
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