ArticleNature and science of sleep2022
The Association Between Sleep Breathing Impairment Index and Cardiovascular Risk in Male Patients with Obstructive Sleep Apnea.
Article in Nature and science of sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 22 citations in OpenAlex.
- Nonlinear age-related differences in clinical profiles of obstructive sleep apnea: a cross-sectional study of 1,508 Chinese patients.Sleep & breathing = Schlaf & Atmung · 2026Article
- Modified Sleep Apnea Severity Index and Cardiovascular Risk in CPAP-Intolerant OSA Patients.The Laryngoscope · 2026Article
- Analysis of the predictive ability of novel hypoxia-related indicators for disease severity in obstructive sleep apnea syndrome.Sleep & breathing = Schlaf & Atmung · 2026Article
- Development and Validation of an Explainable Machine Learning Model for Identifying Hypertension Status in Patients With Obstructive Sleep Apnea.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Association between sleep apnea-specific novel hypoxic metrics and disturbances in glucose and lipid metabolism.Frontiers in endocrinology · 2025Article
- Independent Association of Sleep Apnea-Specific Hypoxic Burden and Sleep Breathing Impairment Index with Thyroid Function in Obstructive Sleep Apnea: A Retrospective Study.Nature and science of sleep · 2025Article
- Hypoxic Burden and T90% as Predictive Indicators of Cardiovascular Risk and Myocardial Ischemia in Patients with Obstructive Sleep Apnea.Nature and science of sleep · 2025Article
- Up-to-date advance in the relationship between obstructive sleep apnea and heart failure: a narrative review.Sleep & breathing = Schlaf & Atmung · 2024Review
- Incremental values of AOPP, IL-6, and GDF15 for identifying arteriosclerosis in patients with obstructive sleep apnea.European journal of medical research · 2024Article
- The Association of High Arousal Threshold with Hypertension and Diabetes in Obstructive Sleep Apnea.Nature and science of sleep · 2024Article
- Urinary Epinephrine Sulfate Can Predict Cardiovascular Risk in Moderate-to-Severe OSA: A Metabolomics-Based Study.Nature and science of sleep · 2024Article
- Sleep apnea pathophysiology.Sleep & breathing = Schlaf & Atmung · 2023Review
- Redefining Comorbid Insomnia and Sleep Apnea: The Association of Sleep Breathing Impairment and Insomnia with Incident Diabetes.Annals of the American Thoracic Society · 2023Article
- Obstructive sleep apnoea heterogeneity and cardiovascular disease.Nature reviews. Cardiology · 2023Review
- The effectiveness of sleep breathing impairment index in assessing obstructive sleep apnea severity.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Shorter respiratory event duration is related to prevalence of type 2 diabetes.Frontiers in endocrinology · 2023Article
- New Metrics from Polysomnography: Precision Medicine for OSA Interventions.Nature and science of sleep · 2023Review
- Sleep and Stroke: Opening Our Eyes to Current Knowledge of a Key Relationship.Current neurology and neuroscience reports · 2022Review
- Risk of Cardiovascular Disease in Apnoeic Individuals: Role of Comorbid Insomnia Disorder.Life (Basel, Switzerland) · 2022Article
- Association of sleep-related disorders with cardiovascular disease among adults in the United States: A cross-sectional study based on national health and nutrition examination survey 2005-2008.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObstructive sleep apnea (OSA) is related to multiple complications including insulin resistance (IR), endothelial dysfunction, and increased risk of cardiovascular disease (CVD). The apnea-hypopnea index (AHI) was widely used to measure OSA severity but poorly correlated with complications above. This study aimed to evaluate whether a new metric, the sleep breathing impairment index (SBII), was associated with cardiovascular risk in patients with OSA.
methodsThis study enrolled 140 consecutive male OSA patients without overt atherosclerotic CVD events, including coronary heart disease, stroke, peripheral vascular disease, or heart failure. Data on baseline medical history, anthropometric and polysomnographic parameters, fasting biochemical measurements and endothelial function tests, and common questionnaires were collected. The SBII was calculated by the product of the duration of each obstructive event and the associated desaturation area. The primary outcome was the moderate-to-high Framingham 10-year CVD risk.
resultsThe median age of enrolled patients was 40 (35-48) years. Eighty subjects had a moderate-to-high Framingham CVD risk. Patients with SBII in the third and fourth quartile had an increased proportion of moderate-to-high Framingham CVD risk with an adjusted OR 6.28 (95% CI 1.10-36.04) and 11.78 (95% CI 1.25-111.38). Significant association was not demonstrated in AHI and the Framingham CVD risk.
conclusionHigher SBII was associated with an increased 10-year CVD risk after adjusting for multiple potential confounding factors. Additional valuable information derived from polysomnography besides AHI deserves to be paid more attention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.