ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2022
Custom-Molded Offloading Footwear Effectively Prevents Recurrence and Amputation, and Lowers Mortality Rates in High-Risk Diabetic Foot Patients: A Multicenter, Prospective Observational Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 68 citations in OpenAlex.
- Interpretable machine learning model for predicting recurrence in patients with diabetic foot ulcers.BMJ open diabetes research & care · 2025Article
- Addressing Balance Issues in Diabetic Foot Ulcer Patients: Offloading, Mobility, and Fall Prevention.Cureus · 2025Review
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- Transforming the Management of Articular Fractures in the Foot: A Critical Examination of Current Methods and Future Directions: A Review.Journal of personalized medicine · 2024Review
- A New Fast Control Strategy of Terminal Sliding Mode with Nonlinear Extended State Observer for Voltage Source Inverter.Sensors (Basel, Switzerland) · 2023Article
- Numerical Simulation and Analysis of Turbulent Characteristics near Wake Area of Vacuum Tube EMU.Sensors (Basel, Switzerland) · 2023Article
- Advances in the Clinical Application of Platelet-Rich Plasma in the Foot and Ankle: A Review.Journal of clinical medicine · 2023Review
- An Efficient End-to-End Multitask Network Architecture for Defect Inspection.Sensors (Basel, Switzerland) · 2022Article
- A Multi-Strategy Adaptive Comprehensive Learning PSO Algorithm and Its Application.Entropy (Basel, Switzerland) · 2022Article
- An effective behavior recognition method in the video session using convolutional neural network.PloS one · 2022Article
- Biomechanical Analysis and Training Method Research on Head Shot Strength of Football Players.Journal of healthcare engineering · 2022Article
- The role of allogeneic platelet-rich plasma in patients with diabetic foot ulcer: Current perspectives and future challenges.Frontiers in bioengineering and biotechnology · 2022Review
- The Evaluation of Gait and Balance for Patients with Early Diabetic Peripheral Neuropathy: A Cross-Sectional Study.Risk management and healthcare policy · 2022Article
- Improved Sparrow Algorithm Based on Game Predatory Mechanism and Suicide Mechanism.Computational intelligence and neuroscience · 2022Review
- Fault Recognition Method Based on Attention Mechanism and the 3D-UNet.Computational intelligence and neuroscience · 2022Article
- The Validity and Efficacy of a Preventative Intervention Model for Reducing Ulcer Recurrence in Diabetic Patients in Indonesia.SAGE open nursingArticle
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Authors and funding
17 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundRecurrence of high-risk diabetic feet, after wound, healing is a common challenge among diabetic patients. Continuous use of an offloading device significantly prevents recurrence of high-risk diabetic feet, although patient adherence is imperative to ensuring this therapy's clinical efficacy. In this study, we explored clinical outcomes of patients with a high-risk diabetic foot who had been prescribed with custom-molded offloading footwear under different adherence conditions.
methodsA total of 48 patients (17 females and 31 males) with high-risk diabetic feet, who had been with prescribed offloading footwear in 13 medical centers across 4 cities, were enrolled in the current study. The patients were assigned into either continuous offloading therapy (COT, n = 31) or interrupted offloading therapy (IOT, n = 17) groups, according to their adherence to the therapy. All patients were followed up monthly, and differences in recurrence, amputation, and deaths between the groups were analyzed at 4 months after therapy.
resultsForty-eight patients met our inclusion criteria and were therefore included in the final analysis. Among them, 31 were stratified into the COT group and adhered to offloading therapy throughout the study period, whereas 17 were grouped as IOT and exhibited interrupted adherence to offloading therapy. We found statistically significant differences in recurrence rates (0 vs 38.46%, p < 0.01), amputation (0 vs 11.76%, p < 0.01), and deaths (0% vs 5.88%, p < 0.01) between the groups during follow-up.
conclusionPatients' adherence is imperative to efficacy of custom-molded offloading footwear during treatment of high-risk diabetic foot. Further studies are needed to elucidate the role of improved design of the offloading device and the need for enhanced patient education for improved adherence.
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