Evidence map›Paper›PMID 35046617›Full record

ArticleCurrent directions in psychological science2021

A Transdiagnostic Perspective on Youth Irritability.

Daniel N Klein, Lea R Dougherty, Ellen M Kessel, Jamilah Silver, Gabrielle A Carlson

Open access · greenAbstract read
In one paragraph

Article in Current directions in psychological science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Associations of Tonic and Phasic Irritability With Psychopathology Subfactors of the Hierarchical Taxonomy of Psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2026
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  18. Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Daniel N KleinDepartment of Psychology, Stony Brook University.
Lea R DoughertyDepartment of Psychology, University of Maryland, College Park.
Ellen M KesselDivision of Child and Adolescent Psychiatry, Columbia University and New York State Psychiatric Institute.
Jamilah SilverDepartment of Psychology, Stony Brook University.
Gabrielle A CarlsonDepartment of Psychiatry, Stony Brook University School of Medicine.
Stony Brook University · USNew York Psychoanalytic Society and Institute · USUniversity of Maryland, College Park · US

Funding

Temperamental Low PE in Preschoolers and Depression RiskR01MH069942 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI KLEIN, DANIEL N · 2004 to 2023
$14.2M
Translational Research Training in Child PsychiatryT32MH016434 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Cristiane S. Duarte, Kate Dimond Fitzgerald · 1985 to 2026
$10.9M
Neural mechanisms of risk and resilience in early childhood irritability (Diversity Supplement - E. Peterson)R01MH121385 · NIMH · SAN DIEGO STATE UNIVERSITY · PI DOUGHERTY, LEA R, WIGGINS, JILLIAN LEE · 2020 to 2024
$3.7M
Neural mechanisms of risk for irritability across the transition to adolescenceR01MH122487 · NIMH · SAN DIEGO STATE UNIVERSITY · PI DOUGHERTY, LEA R, WIGGINS, JILLIAN LEE · 2021 to 2025
$1.8M
NIMH NIH HHS R01 MH069942NIMH NIH HHS R01 MH121385NIMH NIH HHS R01 MH122487NIMH NIH HHS T32 MH016434
6 · The paper itself

Abstract

Irritability is increasingly recognized as a significant clinical problem in youth. It is a criterion for multiple diagnoses and predicts the development of a wide range of disorders. Research on etiopathogenesis suggests that genetic and family environmental factors play a role, as do abnormalities in reward and cognitive control circuitry. However, many of these effects are age dependent. Threat-responsive self-regulatory systems and the degree to which irritability manifests as tonic or phasic influence whether irritable youth exhibit more internalizing versus externalizing outcomes.

Indexed as

irritabilitytemper losstransdiagnosticyouth

Identifiers

PMID35046617
PMCPMC8765598
OpenAlexW3200814391

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.