Evidence map›Paper›PMID 35046616›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2019

Genetically encoded FRET probes for direct mapping and quantification of intracellular oxygenation level via fluorescence lifetime imaging.

Alessio Andreoni, Rozhin Penjweini, Branden Roarke, Marie-Paule Strub, Dan L Sackett, Jay R Knutson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Fluorescence lifetime imaging ofProceedings of SPIE--the International Society for Optical Engineering
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alessio AndreoniLaboratory of Advanced Microscopy and Biophotonics.
Rozhin PenjweiniLaboratory of Advanced Microscopy and Biophotonics.
Branden RoarkeLaboratory of Advanced Microscopy and Biophotonics.
Marie-Paule StrubLaboratory of Structural Biophysics, Biochemistry and Biophysics Center, National Heart Lung and Blood Institute (NIH).
Dan L SackettCell Biophysics, National Institute of Child Health and Human Development (NIH).
Jay R KnutsonLaboratory of Advanced Microscopy and Biophotonics.
National Institutes of Health · US

Funding

Multiphoton Microscopy DevelopmentZIAHL006065 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KNUTSON, JAY R · 2010 to 2025
$11.4M
Intramural NIH HHS ZIA HL006065
6 · The paper itself

Abstract

Molecular oxygen is an important reporter of metabolic and physiological status at the cellular and tissue level and its concentration is used for the evaluation of many diseases (e.g.: cancer, coronary artery disease). The development of accurate and quantitative methods to measure O

Indexed as

Biosensorsfluorescence lifetime imaging (FLIM)FRETliving cellsMyo-mCherryOxygen sensingprotein engineering

Identifiers

PMID35046616
PMCPMC8765217
OpenAlexW2917280044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.