Evidence map›Paper›PMID 35046522›Full record

ArticleNature human behaviour2022

Sense of agency for intracortical brain-machine interfaces.

Andrea Serino, Marcia Bockbrader, Tommaso Bertoni, Sam Colachis Iv, Marco Solcà, Collin Dunlap, Kaitie Eipel, Patrick Ganzer, Nick Annetta, Gaurav Sharma and 6 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature human behaviour, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
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  5. Dopaminergic modulation of the sense of agency influences moral behavior in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Toward brain-trained humanoid robots.Frontiers in neurorobotics · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 3 countries.

Andrea Serino *MySpace Lab, Department of Clinical Neuroscience, University Hospital Lausanne (CHUV), Lausanne, Switzerland. andrea.serino@unil.ch.ORCID http://orcid.org/0000-0001-7475-6095
Marcia Bockbrader *Department of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-6419-0630
Tommaso BertoniMySpace Lab, Department of Clinical Neuroscience, University Hospital Lausanne (CHUV), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-4798-7733
Sam Colachis IvDepartment of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, OH, USA.
Marco SolcàLaboratory of Cognitive Neuroscience, Brain Mind Institute & Center for Neuroprosthetics, Ecole Polytechnique Fèdèrale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland.
Collin DunlapDepartment of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, OH, USA.
Kaitie EipelDepartment of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, OH, USA.
Patrick GanzerMedical Devices and Neuromodulation, Battelle Memorial Institute, Columbus, OH, USA.ORCID http://orcid.org/0000-0003-4260-1624
Nick AnnettaMedical Devices and Neuromodulation, Battelle Memorial Institute, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-4236-6356
Gaurav SharmaMedical Devices and Neuromodulation, Battelle Memorial Institute, Columbus, OH, USA.
Pavo OrepicLaboratory of Cognitive Neuroscience, Brain Mind Institute & Center for Neuroprosthetics, Ecole Polytechnique Fèdèrale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-6965-7578
David FriedenbergMedical Devices and Neuromodulation, Battelle Memorial Institute, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-4404-8941
Per SederbergDepartment of Psychology, University of Virginia, Charlottesville, VA, USA.
Nathan FaivreLaboratory of Cognitive Neuroscience, Brain Mind Institute & Center for Neuroprosthetics, Ecole Polytechnique Fèdèrale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-6011-4921
Ali RezaiDepartment of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, OH, USA.
Olaf BlankeLaboratory of Cognitive Neuroscience, Brain Mind Institute & Center for Neuroprosthetics, Ecole Polytechnique Fèdèrale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland. olaf.blanke@epfl.ch.ORCID http://orcid.org/0000-0002-9745-3983
Battelle · USÉcole Polytechnique Fédérale de Lausanne · CHCentre National de la Recherche Scientifique · FRCollege of Saint Elizabeth · USDefense Engineering Corporation (United States) · USUnited States Air Force Research Laboratory · USUniversity Hospital of Geneva · CHUniversity of Virginia · USWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracortical brain-machine interfaces decode motor commands from neural signals and translate them into actions, enabling movement for paralysed individuals. The subjective sense of agency associated with actions generated via intracortical brain-machine interfaces, the neural mechanisms involved and its clinical relevance are currently unknown. By experimentally manipulating the coherence between decoded motor commands and sensory feedback in a tetraplegic individual using a brain-machine interface, we provide evidence that primary motor cortex processes sensory feedback, sensorimotor conflicts and subjective states of actions generated via the brain-machine interface. Neural signals processing the sense of agency affected the proficiency of the brain-machine interface, underlining the clinical potential of the present approach. These findings show that primary motor cortex encodes information related to action and sensing, but also sensorimotor and subjective agency signals, which in turn are relevant for clinical applications of brain-machine interfaces.

Indexed as

Brain-Computer InterfacesHumansMovement

Identifiers

PMID35046522
OpenAlexW4206378667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.