ReviewHypertension research : official journal of the Japanese Society of Hypertension2022
Impact of hyperuricemia on chronic kidney disease and atherosclerotic cardiovascular disease.
Review in Hypertension research : official journal of the Japanese Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- The link between hyperuricemia and diabetes: insights from a quantitative analysis of scientific literature.Frontiers in endocrinology · 2024Pooled it
- Effect of the Xanthine Oxidase Inhibitor Febuxostat on the Cardio-Ankle Vascular Index in Asymptomatic Patients with Hyperuricemia and Liver Dysfunction: A Sub-Analysis of the PRIZE Study.Journal of atherosclerosis and thrombosis · 2025Trial
- Febuxostat and renal outcomes: post-hoc analysis of a randomized trial.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Trial
- Poly(bromocresol green) modified screen-printed carbon electrode for selective voltametric detection of uric acid.RSC advances · 2026Article
- Hyperuricemia and Hypoxic Pulmonary Hypertension: Pathogenic Links, Clinical Evidence, and Emerging Therapeutic Insights.Cardiovascular drugs and therapy · 2026Review
- Prevalence of Asymptomatic Hyperuricemia and Associated Factors in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study in Southern Vietnam.Diagnostics (Basel, Switzerland) · 2026Article
- Targeting CCDC90B restores intestinal stem cell function under hyperuricemic stress.Stem cell reports · 2026Article
- Dietary intake and hyperuricemia among US adults: A matched case-control analysis of NHANES 2001-2020.Medicine · 2026Article
- Clematis Chinensis Attenuates Hyperuricemia Through the Coordinated Regulation of Purine Metabolism and Inflammatory Responses: An Integrative Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Uric Acid-Reducing Potential of Limosilactobacillus Fermentum FOSU YHD19: A Comprehensive Genomic and Phenotypic Study.Probiotics and antimicrobial proteins · 2026Article
- National Prevalence, Regional Distribution, and Risk Factors for CKD in Taiwan.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Renin-Independent Aldosteronism Heightened the Risk of Renal Impairment in Chinese Adults From Hakka Biobank.Kidney medicine · 2026Article
- Diuretic and Anti-hyperuricemic Effects of Geranyl Acetate in Rats.Current medicinal chemistry · 2026Article
- Higher serum uric acid levels are associated with an increased risk of carotid atherosclerosis in 67,256 adults.Frontiers in nutrition · 2026Article
- Association between numbing-spicy related dietary behavior and hyperuricemia in a Southwestern Chinese population.Frontiers in nutrition · 2026Article
- Dual Mechanisms of Naru Sanwei Pills in Gout: NLRP3 Inflammasome Inhibition and Uric Acid Regulation.Journal of inflammation research · 2026Article
- Article
- Uric Acid Trajectories and CKD Progression in the African American Study of Kidney Disease and Hypertension.Kidney international reports · 2025Article
- Serum Uric Acid as a Potential Risk Marker for Atherosclerotic Cardiovascular Disease in Japanese Adults: Using the Hisayama Study-based Prediction Model.JMA journal · 2025Review
- From plateau to plains: unraveling the diet-exercise paradox in uric acid homeostasis through a comprehensive comparative study.Clinical rheumatology · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperuricemia is caused by reduced renal/extrarenal excretion and overproduction of uric acid. It is affected by genetic predisposition related to uric acid transporters and by visceral fat accumulation due to overnutrition. The typical symptomatic complication of hyperuricemia is gout caused by monosodium urate crystals. Accumulated evidence from epidemiological studies suggests that hyperuricemia is also a risk factor for hypertension, chronic kidney disease (CKD) and atherosclerotic cardiovascular disease (CVD). However, it remains to be determined whether urate-lowering therapy for asymptomatic patients with hyperuricemia is effective in preventing CKD or CVD progression. This mini review focuses mainly on recent papers investigating the relationship between hyperuricemia and CKD or CVD and studies of urate-lowering therapy. Accumulated studies have proposed mechanisms of renal damage and atherosclerosis in hyperuricemia, including inflammasome activation, decreased nitric oxide bioavailability and oxidative stress induced by uric acid, urate crystals and xanthine oxidoreductase (XOR)-mediated reactive oxygen species. Since patients with hyperuricemia are a heterogeneous population with complex pathologies, it may be important to assess whether an outcome is the result of decreasing serum uric acid levels or an inhibitory effect on XOR. To clarify the impact of hyperuricemia on CKD and CVD progression, high-quality and detailed clinical and basic science studies of hyperuricemia and purine metabolism are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.