Evidence map›Paper›PMID 35046466›Full record

ArticleScientific reports2022

Genome and transcriptome profiling of spontaneous preterm birth phenotypes.

Juhi K Gupta, Angharad Care, Laura Goodfellow, Zarko Alfirevic, Bertram Müller-Myhsok, Ana Alfirevic

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Protective Effect ofInternational journal of molecular sciences · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Systematic review of preterm birth multi-omic biomarker studies.Expert reviews in molecular medicine · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Juhi K GuptaWolfson Centre for Personalised Medicine, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Block A: Waterhouse Buildings, 1-5 Brownlow Street, Liverpool, L69 3GL, UK. J.Gupta@liverpool.ac.uk.
Angharad CareHarris-Wellbeing Research Centre, University Department, Liverpool Women's Hospital, Liverpool, L8 7SS, UK.
Laura GoodfellowHarris-Wellbeing Research Centre, University Department, Liverpool Women's Hospital, Liverpool, L8 7SS, UK.
Zarko AlfirevicHarris-Wellbeing Research Centre, University Department, Liverpool Women's Hospital, Liverpool, L8 7SS, UK.
Bertram Müller-MyhsokWolfson Centre for Personalised Medicine, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Block A: Waterhouse Buildings, 1-5 Brownlow Street, Liverpool, L69 3GL, UK.
Ana AlfirevicWolfson Centre for Personalised Medicine, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Block A: Waterhouse Buildings, 1-5 Brownlow Street, Liverpool, L69 3GL, UK.
University of Liverpool · GBLiverpool Women's Hospital · GBMax Planck Institute of Psychiatry · DE

Funding

Wellbeing of Women Harris-Wellbeing Preterm Birth CentreWellcome TrustWellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

Preterm birth (PTB) occurs before 37 weeks of gestation. Risk factors include genetics and infection/inflammation. Different mechanisms have been reported for spontaneous preterm birth (SPTB) and preterm birth following preterm premature rupture of membranes (PPROM). This study aimed to identify early pregnancy biomarkers of SPTB and PPROM from the maternal genome and transcriptome. Pregnant women were recruited at the Liverpool Women's Hospital. Pregnancy outcomes were categorised as SPTB, PPROM (≤ 34 weeks gestation, n = 53), high-risk term (HTERM, ≥ 37 weeks, n = 126) or low-risk (no history of SPTB/PPROM) term (LTERM, ≥ 39 weeks, n = 188). Blood samples were collected at 16 and 20 weeks gestation from which, genome (UK Biobank Axiom array) and transcriptome (Clariom D Human assay) data were acquired. PLINK and R were used to perform genetic association and differential expression analyses and expression quantitative trait loci (eQTL) mapping. Several significant molecular signatures were identified across the analyses in preterm cases. Genome-wide significant SNP rs14675645 (ASTN1) was associated with SPTB whereas microRNA-142 transcript and PPARG1-FOXP3 gene set were associated with PPROM at week 20 of gestation and is related to inflammation and immune response. This study has determined genomic and transcriptomic candidate biomarkers of SPTB and PPROM that require validation in diverse populations.

Indexed as

Gene Expression ProfilingGenome-Wide Association StudyAdultBiomarkersFemaleForkhead Transcription FactorsHumansMicroRNAsNerve Tissue ProteinsPPAR gammaPregnancyPregnancy OutcomePremature BirthPremature Rupture of Fetal MembranesQuantitative Trait LociReceptors, Cell SurfaceASTN1 protein, humanBiomarkersForkhead Transcription FactorsFOXP3 protein, humanMicroRNAsMIRN142 microRNA, humanNerve Tissue ProteinsPPAR gammaReceptors, Cell Surface

Identifiers

PMID35046466
PMCPMC8770724
OpenAlexW4205959765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.