ArticleNature communications2022
Merging enzymes with chemocatalysis for amide bond synthesis.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Amide-functionalized cholic acid hybrids: design, bioactivity, and computational analysis.RSC advances · 2026Article
- Article
- Recent Advances in Metal-Based Catalysts for Nitrile Hydration to Amides: Mechanistic Aspects.Chemical record (New York, N.Y.) · 2026Review
- A tailored CoA ligase-Nature catalysis · 2026Article
- Skeletal Editing of Alkenes with Nitroarenes via Photoinduced Rearrangement of N─O═C Dipoles Forms Lactams and Amides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Aminoacyl-tRNA Specificity of a Ligase Catalyzing Non-ribosomal Peptide Extension.Journal of the American Chemical Society · 2025Article
- Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol.Angewandte Chemie (International ed. in English) · 2025Article
- Enzymatic Cascades for Stereoselective and Regioselective Amide Bond Assembly.Angewandte Chemie (International ed. in English) · 2025Article
- Directed Evolution of a Modular Polyketide Synthase Thioesterase for Generation of a Hybrid Macrocyclic Ring System.ACS catalysis · 2025Article
- β-Silyl alkynoates: Versatile reagents for biocompatible and selective amide bond formation.Science advances · 2024Article
- Light Controlled Nanobiohybrids for Modulating Chiral Alcohol Synthesis.Applied biochemistry and biotechnology · 2024Article
- Ferrocenyl conjugated oxazepines/quinolines: multiyne coupling and ring-expanding or rearrangement.Frontiers in chemistry · 2024Article
- Opportunities and Challenges of Metal-Organic Framework Micro/Nano Reactors for Cascade Reactions.JACS Au · 2023Review
- Non-Native Site-Selective Enzyme Catalysis.Chemical reviews · 2023Review
- A Sustainable Green Enzymatic Method for Amide Bond Formation.Molecules (Basel, Switzerland) · 2023Article
- Development of fluorous boronic acid catalysts integrated with sulfur for enhanced amidation efficiency.RSC advances · 2023Article
- Chemical Constituents of the MushroomMolecules (Basel, Switzerland) · 2023Article
- Effective Production of Selected Dioxolanes by Sequential Bio- and Chemocatalysis Enabled by Adapted Solvent Switching.ChemSusChem · 2023Article
- Combined chemoenzymatic strategy for sustainable continuous synthesis of the natural product hordenine.Green chemistry : an international journal and green chemistry resource : GC · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Amides are one of the most fundamental chemical bonds in nature. In addition to proteins and other metabolites, many valuable synthetic products comprise amide bonds. Despite this, there is a need for more sustainable amide synthesis. Herein, we report an integrated next generation multi-catalytic system, merging nitrile hydratase enzymes with a Cu-catalysed N-arylation reaction in a single reaction vessel, for the construction of ubiquitous amide bonds. This synergistic one-pot combination of chemo- and biocatalysis provides an amide bond disconnection to precursors, that are orthogonal to those in classical amide synthesis, obviating the need for protecting groups and delivering amides in a manner unachievable using existing catalytic regimes. Our integrated approach also affords broad scope, very high (molar) substrate loading, and has excellent functional group tolerance, telescoping routes to natural product derivatives, drug molecules, and challenging chiral amides under environmentally friendly conditions at scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.