ArticleScientific reports2022
High speed, long range, deep penetration swept source OCT for structural and angiographic imaging of the anterior eye.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Automated dual-camera DMD system for stereo optical sectioning imaging.Biomedical optics express · 2026Article
- Single-shot, depth-encoded multiplexed OCT for multi-spot tracking of induced transient corneal dynamics.Biomedical optics express · 2026Article
- Three-dimensional assessment of posterior polymorphous corneal dystrophy with swept-source optical coherence tomography.Quantitative imaging in medicine and surgery · 2026Article
- Imaging of Ocular Surface Lesions Using Anterior Segment Optical Coherence Tomography.Clinical & experimental ophthalmology · 2026Review
- Dynamic optical coherence microscope integrated with cell-cultivation chamber enabled longitudinal and early-stage assessment of tumor spheroid-drug interaction.Scientific reports · 2026Article
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- Recent Progress in Liquid Microlenses and Their Arrays for Adaptive and Applied Optical Systems.Micromachines · 2025Review
- Widefield OCT angiography.Progress in retinal and eye research · 2025Review
- Advances in OCT Angiography.Translational vision science & technology · 2025Review
- A microcomb-empowered Fourier domain mode-locked LIDAR.Science advances · 2025Article
- Development of next generation low-cost OCT towards improved point-of-care retinal imaging.Biomedical optics express · 2025Article
- Multi-modality imaging technologies and machine learning for non-invasive, precise assessment of rabbit endometrium.Biomedical optics express · 2025Article
- Review
- Stereo slit-scanning tomography of the anterior segment of the human eye.Scientific reports · 2024Article
- Anterior segment optical coherence tomography for the detection of silicone oil emulsification on the iris surface.Eye (London, England) · 2024Article
- A novel stress sensor enables accurate estimation of micro-scale tissue mechanics in quantitative micro-elastography.APL bioengineering · 2024Article
- Adaptive contour-tracking to aid wide-field swept-source optical coherence tomography imaging of large objects with uneven surface topology.Biomedical optics express · 2024Article
- Exploring single-mode VCSEL wavelength tuning for low-cost 3D optical coherence tomography and OCT angiography.Biomedical optics express · 2024Article
- Polarization-artifact reduction and accuracy improvement of Jones-matrix polarization-sensitive optical coherence tomography by multi-focus-averaging based multiple scattering reduction.Biomedical optics express · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
This study reports the development of prototype swept-source optical coherence tomography (SS-OCT) technology for imaging the anterior eye. Advances in vertical-cavity surface-emitting laser (VCSEL) light sources, signal processing, optics and mechanical designs, enable a unique combination of high speed, long range, and deep penetration that addresses the challenges of anterior eye imaging. We demonstrate SS-OCT with a 325 kHz A-scan rate, 12.2 µm axial resolution (in air), and 15.5 mm depth range (in air) at 1310 nm wavelength. The ultrahigh 325 kHz A-scan rate not only facilitates biometry measurements by minimizing acquisition time and thus reducing motion, but also enables volumetric OCT for comprehensive structural analysis and OCT angiography (OCTA) for visualizing vasculature. The 15.5 mm (~ 11.6 mm in tissue) depth range spans all optical surfaces from the anterior cornea to the posterior lens capsule. The 1310 nm wavelength range enables structural OCT and OCTA deep in the sclera and through the iris. Achieving high speed and long range requires linearizing the VCSEL wavenumber sweep to efficiently utilize analog-to-digital conversion bandwidth. Dual channel recording of the OCT and calibration interferometer fringe signals, as well as sweep to sweep wavenumber compensation, is used to achieve invariant 12.2 µm (~ 9.1 µm in tissue) axial resolution and optimum point spread function throughout the depth range. Dynamic focusing using a tunable liquid lens extends the effective depth of field while preserving the lateral resolution. Improved optical and mechanical design, including parallax "split view" iris cameras and stable, ergonomic patient interface, facilitates accurate instrument positioning, reduces patient motion, and leads to improved imaging data yield and measurement accuracy. We present structural and angiographic OCT images of the anterior eye, demonstrating the unique imaging capabilities using representative scanning protocols which may be relevant to future research and clinical applications.
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