ArticleScientific reports2022
The gut microbiota of chickens in a commercial farm treated with a Salmonella phage cocktail.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 49 citations in OpenAlex.
- Gut microbiota in poultry: Roles in nutrition, metabolism and production performance.Poultry science · 2026Review
- The chicken gut virome: spatial structuring and extensive diversity of 19,778 viral populations.mSystems · 2026Article
- Assessing the impact of phage therapy on growth performance, microbiome and phage specific immune response in chickens.Scientific reports · 2026Article
- Recurrent phage treatment of Salmonella-infected chickens transiently reshapes gut microbiota composition and function.Veterinary research · 2026Article
- Isolation and Characterization of the Polyvalent Enterobacteria-Infecting Phage Cit2 with Potential for Biocontrol Applications.ACS omega · 2026Article
- Starter feed enhances growth, antioxidant capacity, and gut microbiota in Chawula yak calves.Scientific reports · 2026Article
- Antibiotic growth promoter and phytogenic feed additive consistently alter microbial community structure in chicken cecum.Frontiers in microbiology · 2026Article
- Bacteriophage cocktail in drinking water suppresses systemic avian pathogenicCurrent research in microbial sciences · 2026Article
- Morphological and complete genome analysis of a novelFrontiers in pharmacology · 2026Article
- Gut microbiota profile, potential engineering techniques and its genetic and epigenetic implications in poultry health.World journal of microbiology & biotechnology · 2025Review
- Improving health and productivity in laying hens with the phage cocktail SalmoFree®.Poultry science · 2025Article
- Effects of DietaryVeterinary sciences · 2025Article
- Decoding the human phageome helps to unravel microbial dynamics in health and disease.Applied and environmental microbiology · 2025Article
- Evolutionary responses of Escherichia coli to phage pressure: insights into mucoidy and colanic acid overexpression.BMC genomics · 2025Article
- Characterization of Newly IsolatedMicroorganisms · 2025Article
- Applications of bacteriophages in precision engineering of the human gut microbiome.Engineering microbiology · 2025Review
- Decoding the chicken gastrointestinal microbiome.BMC microbiology · 2025Article
- Prophylactic phage administration reduces Salmonella Enteritidis infection in newly hatched chicks.MicrobiologyOpen · 2024Article
- The effect of peanut skins as a natural antimicrobial feed additive on ileal and cecal microbiota in broiler chickens inoculated with Salmonella enterica Enteritidis.Poultry science · 2024Article
- SalmoFreePHAGE (New Rochelle, N.Y.) · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The microbiota in broiler chicken intestines affects the animals' health, metabolism, and immunity both positively and negatively. Accordingly, it has a significant impact on animal productivity. Phages, host-specific parasites of bacterial cells, are a promising antimicrobial alternative that selectively target pathogens without disturbing the microbiota. The purpose of this study is to further characterize the commensal microbial community at production scale in broiler chickens treated with a Salmonella phage treatment. We evaluated the cecal microbiota of broilers reared in a commercial farming system where a phage cocktail against Salmonella, SalmoFree was supplied to animals. To do so, two field trials were conducted, incorporating three doses of phages in the broilers' drinking water. Our results showed that the core microbiome (taxa that were present in more than 50% of samples) contained species that are key to microbiota adaptation in the last stage of the production cycle. Among these, there are some important degraders of complex polysaccharides and producers of short chain fatty acids (SCFA) such as Eisenbergiella and Lachnoclostridium. The phage cocktail did not affect the normal development of the microbiota's structure. The addition of the phage cocktail resulted in a significant reduction in Campylobacter and an increase in Butyricimonas, Helicobacter and Rikenellaceae, which are common inhabitants in chicken gut with known negative and positive effects on their health and metabolism. Altogether, we consider that these results contribute valuable information to the implementation of large-scale phage therapy technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.