ArticleNature communications2022
Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- ATP2B1 expression identifies human hematopoietic stem cells with superior repopulation and self-renewal.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Lipid nanoparticles for bone marrow-targeted RNA therapeutics.Journal of nanobiotechnology · 2026Review
- Elevated lactate in AML bone marrow contributes to macrophage polarization via GPR81 signaling.Blood advances · 2026Article
- An interesting case of coexistence of autosomal dominant hypocalcemia 1 with Bartter syndrome and chronic myelogenous leukemia.Hormones (Athens, Greece) · 2026Review
- Osteoblast and osteoclast responses to chelate-setting calcium phosphate cements with different solubilities.Biomaterials and biosystems · 2026Article
- Advances in Spatial Transcriptomics in Bone.Current osteoporosis reports · 2026Review
- Pre-therapeutic bone marrow-resident leukemic cells in acute myeloid leukemia exhibit a distinct dysregulated calcium signature and stem-like profile reflecting minimal residual disease precursors.Journal of experimental & clinical cancer research : CR · 2026Article
- A Hidden Checkpoint: Bidirectional pH Remodeling of the Immunological Synapse in Cancer, Methods, and Therapeutic Opportunities.Journal of immunology research · 2026Review
- The interrelationship between calcium-phosphorus homeostasis and bone remodelling. Impact of dietary changes on bone in patients with primary hyperparathyroidism and chronic kidney disease.Frontiers in bioengineering and biotechnology · 2026Article
- Nonionotropic action of an acid-sensing ion channel inhibits leukemogenesis in the acidic bone marrow niche.The Journal of clinical investigation · 2025Article
- Establishment and comprehensive characterization of a subline with highly bone-metastatic propensity derived from the lung adenocarcinoma A549 cell line.Journal of bone oncology · 2025Article
- Reconstruction of hematopoietic stem cell nichesMaterials today. Bio · 2025Review
- Calcium Imaging in Vivo: How to Correctly Select and Apply Fiber Optic Photometric Indicators.Organogenesis · 2025Review
- A microenvironment responsive nanoparticle regulating osteoclast fate to promote bone repair in osteomyelitis.Materials today. Bio · 2025Article
- Elevated Lactate in the AML Bone Marrow Microenvironment Polarizes Leukemia-Associated Macrophages via GPR81 Signaling.bioRxiv : the preprint server for biology · 2025Article
- Acid-Triggered Dual-Functional Hydrogel Platform for Enhanced Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Rheumatoid arthritis severity is mediated by crosstalk between synoviocytes and mature osteoclasts through a calcium and cytokine feedback loop.Experimental & molecular medicine · 2025Article
- Bidirectional crosstalk between the bone extracellular matrix and lysosomes in bone remodeling and osteoporosis.Frontiers in endocrinology · 2025Review
- Architectural Design of Biomaterial Scaffolds for Hematopoietic Stem Cell Culture.Biomaterials research · 2025Review
- Efferocytosis and Bone Dynamics.Current osteoporosis reports · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 1 country.
S-C A Yeh *Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0003-1898-9665
J Hou *Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
J W WuAdvanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
S YuDepartment of Chemistry and Environmental Science, New Jersey Institute of Technology, 323 Martin Luther King Jr. Blvd., Newark, NJ, 07102, USA.
Y ZhangDepartment of Chemistry and Environmental Science, New Jersey Institute of Technology, 323 Martin Luther King Jr. Blvd., Newark, NJ, 07102, USA.
K D BelfieldDepartment of Chemistry and Environmental Science, New Jersey Institute of Technology, 323 Martin Luther King Jr. Blvd., Newark, NJ, 07102, USA.ORCID http://orcid.org/0000-0002-7339-2813
F D CamargoStem Cell Program, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5630-5909
C P LinAdvanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. charles_lin@hms.harvard.edu.ORCID http://orcid.org/0000-0002-7450-627X
Harvard University · USNew Jersey Institute of Technology · USBoston Children's Hospital · US
Funding
PROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MHigh resolution lineage tracing of developmental hematopoiesisR01HL158192 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Fernando Camargo, Sahand Hormoz · 2023 to 2026
$3.0MSingle cell approach to uncovering factors regulating HSC division symmetry in vivoR01DK115577 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ITO, KEISUKE, LIN, CHARLES P. · 2017 to 2021
$2.9MRole and regulation of PRX1 expressing cells during calvarial bone regenerationR01DE026155 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI INTINI, GIUSEPPE · 2019 to 2023
$2.0MImage guided profiling of the native HSC nicheR01DK123216 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CAMARGO, FERNANDO, LIN, CHARLES P. · 2019 to 2021
$941kAlcohol Promotes Waste Metabolites Clearance in the CNSR21AA028340 · NIAAA · NEW JERSEY INSTITUTE OF TECHNOLOGY · PI BELFIELD, KEVIN D. · 2020 to 2021
$395kNHLBI NIH HHS P01 HL142494NHLBI NIH HHS R01 HL158192NIAAA NIH HHS R21 AA028340NIDCR NIH HHS R01 DE026155NIDDK NIH HHS R01 DK115577NIDDK NIH HHS R01 DK123216
Abstract
The fate of hematopoietic stem cells (HSCs) can be directed by microenvironmental factors including extracellular calcium ion concentration ([Ca
Indexed as
Intravital MicroscopyAgingAnimalsBenzopyransBone MarrowBone RemodelingCalciumCellular MicroenvironmentFluorescenceHematopoietic Stem CellsHydrogen-Ion ConcentrationMiceMice, Inbred C57BLNaphtholsRhodaminesBenzopyransCalciumNaphtholsRhodaminesseminaphthorhodaminefluoride
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.