ArticleBMJ open respiratory research2022
Asthma, atopy and lung function in young adults after hospitalisation for bronchiolitis in infancy: impact of virus and sex.
Article in BMJ open respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- A comprehensive look at Respiratory Syncytial Virus (RSV): from pathogenesis to prevention.Tropical diseases, travel medicine and vaccines · 2026Review
- Association between nasal airway metabolome signatures and lung function at age 6 years among children with post-bronchiolitis asthma.ERJ open research · 2026Article
- Metabolomic Approaches to Lung Function in Pediatric Asthma: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Association between early-life respiratory syncytial virus infection and the risk of asthma: a meta-analysis.Journal of thoracic disease · 2025Article
- Bronchial hyper-reactivity in young adults after hospitalisation for bronchiolitis in infancy.BMJ open respiratory research · 2025Article
- Risk factors for recurrent wheezing after infant bronchiolitis: a 6-year single-centre follow up study in China.Frontiers in pediatrics · 2025Article
- Asthma and health-related quality of life at 16-20 years of age in a prospectively followed post-bronchiolitis cohort.European journal of pediatrics · 2024Article
- Bronchiolitis, Regardless of Its Etiology and Severity, Is Associated With Increased Risk of Asthma: A Population-Based Study.The Journal of infectious diseases · 2023Article
- Article
- Characteristics of Respiratory Syncytial Virus versus Influenza Infection in Hospitalized Patients of Peru: A Retrospective Observational Study.Tropical medicine and infectious disease · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHospitalisation for bronchiolitis is a risk factor for asthma and impaired lung function during childhood, but outcomes in young adults are poorly described. Our primary aim was to study the prevalence of asthma and atopy, and lung function at 17-20 years of age after bronchiolitis in infancy and, secondarily, the impact of viral aetiology (respiratory syncytial virus (RSV) vs non-RSV) and sex on these outcomes.
methodsThis Norwegian cohort study enrolled 225 young adults hospitalised for bronchiolitis in infancy during 1996-2001 and 167 matched control subjects. The follow-up included questionnaires for asthma and examinations of lung function and atopy. Outcomes were analysed by mixed effects regressions.
resultsCurrent asthma was more frequent in the postbronchiolitis group versus the control group: 25.1% (95% CI 19.0% to 31.2%) vs 13.1% (95% CI 7.9% to 18.2%), but not atopy: 44.3% (95% CI 37.1% to 51.5%) vs 48.2% (95% CI 40.5% to 55.8%), adjusted predicted proportions (95% CIs). Asthma prevalence did not differ between the RSV group and the non-RSV group: 24.0% (95% CI 16.1% to 32.0%) vs 23.8% (95% CI 12.8% to 34.7%) nor between sexes. Forced expiratory volume in 1 s (FEV
conclusionYoung adults hospitalised for bronchiolitis had higher prevalence of asthma, but not atopy, and a more obstructive lung function pattern than control subjects. The asthma prevalence was high after both RSV bronchiolitis and non-RSV bronchiolitis, and there was no difference between sexes. Bronchiolitis in infancy is associated with respiratory morbidity persisting into young adulthood.
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