Evidence map›Paper›PMID 35046042›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

The flagellar motor protein FliL forms a scaffold of circumferentially positioned rings required for stator activation.

Shoichi Tachiyama, Kar L Chan, Xiaolin Liu, Skander Hathroubi, Briana Peterson, Mohammad F Khan, Karen M Ottemann, Jun Liu, Anna Roujeinikova

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Review
  3. A dramatic protein fold switch powers a bactericidal nanomachine.bioRxiv : the preprint server for biology · 2026
    Article
  4. The ancient E-ring in bacterial flagellar motors.FEMS microbiology reviews · 2026
    Review
  5. Article
  6. Article
  7. FlgY, PflA, and PflB form a spoke-ring network in the high-torque flagellar motor ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Article
  10. Tetrameric PilZ protein stabilizes stator ring in complex flagellar motor and is required for motility inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Review
  12. Article
  13. Molecular model of a bacterial flagellar motorbioRxiv : the preprint server for biology · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Bacterial flagella hijack type IV pili proteins to control motility.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Shoichi TachiyamaDepartment of Microbial Pathogenesis, Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06536.
Kar L ChanInfection and Immunity Program, Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton VIC 3800, Australia.ORCID 0000-0002-7582-2039
Xiaolin LiuDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064.
Skander HathroubiDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-5917-2785
Briana PetersonInfection and Immunity Program, Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton VIC 3800, Australia.
Mohammad F KhanInfection and Immunity Program, Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton VIC 3800, Australia.ORCID 0000-0002-6373-7021
Karen M OttemannDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA 95064; anna.roujeinikova@monash.edu jliu@yale.edu ottemann@ucsc.edu.ORCID 0000-0001-6265-7401
Jun LiuDepartment of Microbial Pathogenesis, Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06536; anna.roujeinikova@monash.edu jliu@yale.edu ottemann@ucsc.edu.ORCID 0000-0003-3108-6735
Anna RoujeinikovaInfection and Immunity Program, Department of Microbiology, Monash Biomedicine Discovery Institute, Monash University, Clayton VIC 3800, Australia; anna.roujeinikova@monash.edu jliu@yale.edu ottemann@ucsc.edu.ORCID 0000-0001-8478-4751
Australian Regenerative Medicine Institute · AUUniversity of California, Santa Cruz · USYale University · US

Funding

Structure-Function Relationships in the Spirochetal Flagellar MotorR01AI087946 · NIAID · YALE UNIVERSITY · PI LIU, JUN · 2010 to 2025
$6.6M
The function of chemotactic signal transduction during colonization and diseaseR01AI116946 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI OTTEMANN, KAREN M · 2016 to 2025
$5.1M
High-throughput electron cryo-microscopeS10OD023603 · OD · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 2018 to 2018
$1.9M
NIAID NIH HHS R01 AI087946NIAID NIH HHS R01 AI116946NIH HHS S10 OD023603
6 · The paper itself

Abstract

The flagellar motor stator is an ion channel nanomachine that assembles as a ring of the MotA

Indexed as

Bacterial Physiological PhenomenaAmino Acid SequenceBacterial ProteinsFlagellaHelicobacter pyloriMembrane ProteinsModels, MolecularMolecular Motor ProteinsMultiprotein ComplexesProtein BindingProtein ConformationProtein Interaction Domains and MotifsProtein TransportStructure-Activity RelationshipBacterial ProteinsFliL protein, BacteriaMembrane ProteinsMolecular Motor ProteinsMultiprotein Complexesbacterial motilityflagellar motorstructure and function

Identifiers

PMID35046042
PMCPMC8794807
OpenAlexW4206215973

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.