Evidence map›Paper›PMID 35046016›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A mitochondrial ADXR-ADX-P450 electron transport chain is essential for maternal gametophytic control of embryogenesis in

Andrés Martin Bellido, Ayelén Mariana Distéfano, Nicolás Setzes, María Milagros Cascallares, Jana Oklestkova, Ondrej Novak, Javier Alberto Ramirez, Eduardo J Zabaleta, Diego F Fiol, Gabriela C Pagnussat

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Contrasting Metabolisms in Green and White Leaf Sectors of VariegatedInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Andrés Martin BellidoInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 7600 Mar del Plata, Argentina.
Ayelén Mariana DistéfanoInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 7600 Mar del Plata, Argentina.ORCID 0000-0003-3763-4501
Nicolás SetzesInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 7600 Mar del Plata, Argentina.
María Milagros CascallaresInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 7600 Mar del Plata, Argentina.ORCID 0000-0001-6185-6759
Jana OklestkovaLaboratory of Growth Regulators, Faculty of Science, Institute of Experimental Botany and Palacký University, The Czech Academy of Sciences, 78371 Olomouc, Czech Republic.ORCID 0000-0002-7423-5537
Ondrej NovakLaboratory of Growth Regulators, Faculty of Science, Institute of Experimental Botany and Palacký University, The Czech Academy of Sciences, 78371 Olomouc, Czech Republic.ORCID 0000-0003-3452-0154
Javier Alberto RamirezDepartamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EGA Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0002-2013-540X
Eduardo J ZabaletaInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 7600 Mar del Plata, Argentina.ORCID 0000-0001-5767-141X
Diego F FiolInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 7600 Mar del Plata, Argentina.ORCID 0000-0003-3666-0185
Gabriela C PagnussatInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 7600 Mar del Plata, Argentina; gpagnussat@mdp.edu.ar.ORCID 0000-0002-6836-3495
Consejo Nacional de Investigaciones Científicas y Técnicas · ARCzech Academy of Sciences, Institute of Experimental Botany · CZ

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Mitochondrial adrenodoxins (ADXs) are small iron-sulfur proteins with electron transfer properties. In animals, ADXs transfer electrons between an adrenodoxin reductase (ADXR) and mitochondrial P450s, which is crucial for steroidogenesis. Here we show that a plant mitochondrial steroidogenic pathway, dependent on an ADXR-ADX-P450 shuttle, is essential for female gametogenesis and early embryogenesis through a maternal effect. The steroid profile of maternal and gametophytic tissues of wild-type (WT) and

Indexed as

AdrenodoxinAmino Acid SequenceArabidopsisCytochrome P-450 Enzyme SystemElectron TransportElectron Transport Chain Complex ProteinsEmbryonic DevelopmentFerredoxin-NADP ReductaseGametogenesisGerm Cells, PlantMitochondriaMitochondrial MembranesPhytosterolsProtein BindingAdrenodoxinCytochrome P-450 Enzyme SystemElectron Transport Chain Complex ProteinsFerredoxin-NADP ReductasePhytosterolsembryogenesisgametophytehomocastasteroneP450plant reproduction

Identifiers

PMID35046016
PMCPMC8794853
OpenAlexW4205974621

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.