Evidence map›Paper›PMID 35046014›Full record

ArticleBMJ open diabetes research & care2022

Prediction of diabetic kidney disease with machine learning algorithms, upon the initial diagnosis of type 2 diabetes mellitus.

Angier Allen, Zohora Iqbal, Abigail Green-Saxena, Myrna Hurtado, Jana Hoffman, Qingqing Mao, Ritankar Das

Abstract read
In one paragraph

Article in BMJ open diabetes research & care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Angier Allen *Research and Development, Dascena, Houston, Texas, USA.ORCID 0000-0001-7808-6244
Zohora Iqbal *Research and Development, Dascena, Houston, Texas, USA.ORCID 0000-0001-7065-8367
Abigail Green-SaxenaResearch and Development, Dascena, Houston, Texas, USA.ORCID 0000-0002-8502-6589
Myrna HurtadoResearch and Development, Dascena, Houston, Texas, USA lhurtado@dascena.com.ORCID 0000-0003-0704-8384
Jana HoffmanResearch and Development, Dascena, Houston, Texas, USA.ORCID 0000-0002-7745-3900
Qingqing MaoResearch and Development, Dascena, Houston, Texas, USA.ORCID 0000-0001-6001-6723
Ritankar DasResearch and Development, Dascena, Houston, Texas, USA.ORCID 0000-0002-1326-844X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDiabetic kidney disease (DKD) accounts for the majority of increased risk of mortality for patients with diabetes, and eventually manifests in approximately half of those patients diagnosed with type 2 diabetes mellitus (T2DM). Although increased screening frequency can avoid delayed diagnoses, this is not uniformly implemented. The purpose of this study was to develop and retrospectively validate a machine learning algorithm (MLA) that predicts stages of DKD within 5 years upon diagnosis of T2DM. RESEARCH DESIGN AND

methodsTwo MLAs were trained to predict stages of DKD severity, and compared with the Centers for Disease Control and Prevention (CDC) risk score to evaluate performance. The models were validated on a hold-out test set as well as an external dataset sourced from separate facilities.

resultsThe MLAs outperformed the CDC risk score in both the hold-out test and external datasets. Our algorithms achieved an area under the receiver operating characteristic curve (AUROC) of 0.75 on the hold-out set for prediction of any-stage DKD and an AUROC of over 0.82 for more severe endpoints, compared with the CDC risk score with an AUROC <0.70 on all test sets and endpoints.

conclusionThis retrospective study shows that an MLA can provide timely predictions of DKD among patients with recently diagnosed T2DM.

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesAlgorithmsHumansMachine LearningRetrospective StudiesUnited Statesalgorithmsdecision support techniquesdiabetes mellituskidney diseasestype 2

Identifiers

PMID35046014
PMCPMC8772425

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.