Evidence map›Paper›PMID 35045890›Full record

ReviewInflammation and regeneration2022

Axon guidance molecules in immunometabolic diseases.

Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh

Open access · goldAbstract readReview
In one paragraph

Review in Inflammation and regeneration, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. PANoptosis in diabetes: immunometabolic insights and treatments.Apoptosis : an international journal on programmed cell death · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Sea lice (Frontiers in genetics · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Alu Deletions inInternational journal of molecular sciences · 2022
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yoshimitsu NakanishiDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita City, Osaka, 565-0871, Japan.
Sujin KangDepartment of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita City, Osaka, 565-0871, Japan.
Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita City, Osaka, 565-0871, Japan. kumanogo@imed3.med.osaka-u.ac.jp.
Osaka University · JPOsaka City University · JP

Funding

the Japan Agency for Medical Research and Development (AMED) J200705023, J200705710, J200705049, JP18cm016335, and JP18cm059042the Japan Agency for Medical Research and Development (AMED)-CREST 15652237the Japan Society for the Promotion of Science (JSPS) KAKENHI JP18H05282the Japan Society for the Promotion of Science (JSPS) KAKENHI JP20K22900
6 · The paper itself

Abstract

The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions. Chronic tissue inflammation is a characteristic of these metabolic diseases, indicating that immune responses are closely involved in the pathogenesis of metabolic disorders. However, the regulatory mechanisms underlying immunometabolic crosstalk in these diseases are not completely understood. Recent studies have revealed the multifaceted functions of semaphorins, originally identified as axon guidance molecules, in regulating tissue inflammation and metabolic disorders, thereby highlighting the functional coupling between semaphorin signaling and immunometabolism. In this review, we explore how semaphorin signaling transcends beyond merely guiding axons to controlling immune responses and metabolic diseases.

Indexed as

AtherosclerosisChronic inflammationDiabetesNeuropilinsObesityPlexinsSemaphorins

Identifiers

PMID35045890
PMCPMC8767680
OpenAlexW4206075628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.