Evidence map›Paper›PMID 35045843›Full record

ArticleBMC medicine2022

The impact of sex and physical performance on long-term mortality in older patients with myocardial infarction.

Elisabetta Tonet, Albert Ariza-Solé, Matteo Serenelli, Francesc Formiga, Juan Sanchis, Rita Pavasini, Pablo Diez-Villanueva, Francesco Vitali, Clara Bonanad, Giovanni Grazzi and 8 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02386124 nacompletednot on this map

Frailty Assessment in eldeRly Admitted to hoSpital for acutE caRdiac Disease Prospective Study

TypeinterventionalSponsorUniversity Hospital of FerraraRan2014 to 2021Enrolled402ConditionsAgedArmsfrailty evaluation
NCT03021044 nacompletednot on this map

Physical Activity Intervention for Patients With Reduced Physical Performance After Acute Coronary Syndrome: a Randomized Clinical Trial (The HULK Pilot Study).

TypeinterventionalSponsorUniversity Hospital of FerraraRan2017 to 2021Enrolled235ConditionsAcute Coronary SyndromeArmsphysical activity intervention, standard of care
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Elisabetta TonetCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy. tonet.elisabetta@gmail.com.ORCID 0000-0003-0257-1272
Albert Ariza-SoléCardiology Department, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Matteo SerenelliCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Francesc FormigaInternal Medicine, Hospital Universitari de Bellvitge, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Juan SanchisCardiology Department, Hospital Clínico de Valencia, INCLIVA, Universidad de Valencia, CIBER CV, Valencia, Spain.
Rita PavasiniCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Pablo Diez-VillanuevaHospital Universitario La Princesa, Madrid, Spain.
Francesco VitaliCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Clara BonanadCardiology Department, Hospital Clínico de Valencia, INCLIVA, Universidad de Valencia, CIBER CV, Valencia, Spain.
Giovanni GrazziPublic Health Department and Center of Sport and Exercise Sciences, University of Ferrara, Ferrara, Italy.
Antoni CarolServicio de Cardiologia, Hospital Moisès Broggi, Sant Joan Despi, Barcelona, Spain.
Giorgio ChiarandaDepartment of Public Health, AUSL Piacenza, and Sport Medicine Service, Piacenza, Italy.
Graziella PompeiCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Laura Sofia CardelliCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Serena CaglioniCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Federico GibiinoCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Stefano VolpatoDepartment of Medical Science, University of Ferrara, Ferrara, Italy.
Gianluca CampoCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy.
Arcispedale Sant'Anna · ITBellvitge University Hospital · ESUniversitat de València · ESUniversity of Ferrara · ITAzienda Unità Sanitaria Locale di Ferrara · ITAzienda Unità Sanitaria Locale Piacenza · ITHospital de Sant Joan Despí Moisès Broggi · ESHospital Universitario de La Princesa · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSex influences outcome of patients with acute coronary syndrome (ACS). If there is a relationship between sex and physical performance is unknown.

methodsThe analysis is based on older (≥70 years) ACS patients included in the FRASER, HULK, and LONGEVO SCA prospective studies. Physical performance was assessed by Short Physical Performance Battery (SPPB). The primary outcome was all-cause mortality.

resultsThe study included 1388 patients, and 441 (32%) were women. At presentation, women were older and more compromised than men. After a median follow-up of 998 [730-1168] days, all-cause death occurred in 334 (24.1%) patients. At univariate analysis, female sex was related to increased risk of death. After adjustments for confounding factors, female sex was no longer associated with mortality. Women showed poor physical performance compared with men (p < 0.001). SPPB values emerged as an independent predictor of death. Including clinical features and SPPB in the multivariable model, we observed a paradigm shift in the prognostic role of female sex that becomes a protective factor (HR 0.73, 95% CI 0.56-0.96). Sex and physical performance showed a significant interaction (p = 0.03). For lower SPPB values (poor physical performance), sex-related changes in mortality were not recorded, while in patients with higher SPPB values (preserved physical performance), female sex was associated with better survival.

conclusionsTwo key findings emerged from the present real-life cohort of older ACS patients: (i) physical performance strongly influences long-term mortality; (ii) women with preserved physical performance have a better outcome compared to men.

trial registrationwww.clinicaltrials.gov NCT02386124 and NCT03021044.

Indexed as

Acute Coronary SyndromeMyocardial InfarctionAgedFemaleHumansMalePhysical Functional PerformancePrognosisProspective StudiesSex FactorsAcute coronary syndromeElderlyMortalityPhysical performanceSex

Identifiers

PMID35045843
PMCPMC8772095
OpenAlexW4205617193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.