ArticleCardiovascular diabetology2022
Correlation of physical and cognitive impairment in diabetic and hypertensive frail older adults.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- The effectiveness of nudge-based physical activity interventions in frail older adults: a systematic review.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults.Frontiers in cardiovascular medicine · 2022Trial
- Association between Traditional Chinese Medicine constitution and geriatric functional impairment evaluated by the integrated care for older people approach in the elderly.Journal of traditional and complementary medicine · 2026Article
- Complementary neuroprotective effects of semaglutide and papaya in diabetic encephalopathy via antioxidant and insulin-signaling pathways.Scientific reports · 2026Article
- Observational
- Editorial: From vulnerability to vigor: innovative approaches in frailty and healthy aging.Frontiers in medicine · 2026Article
- Cognition, Physical Performance, and Fall-Related Mobility Outcomes in Healthy Older Adults: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2025Article
- Statin Use Is Associated With a Decline in Muscle Function and Mass Over Time, Irrespective of Statin Pharmacogenomic Score.Journal of cachexia, sarcopenia and muscle · 2025Article
- Logistic Regression and Machine Learning Algorithms for the Risk Prediction of Perioperative Adverse Cardiovascular Events in Elderly Patients.Aging medicine (Milton (N.S.W)) · 2025Article
- Risk factors for comorbid hypertension in elderly patients with type 2 diabetes.American journal of translational research · 2025Article
- Fall Risk Factors and Other Geriatric Syndromes in Older Adults With Diabetes: Experience of a Multidisciplinary Fall Consultation.Journal of diabetes research · 2025Article
- Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study.Cardiovascular diabetology · 2024Article
- Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study.Journal of translational medicine · 2024Article
- Evaluation of the prevalence of cardiometabolic disorders (diabetes, hypertension, and hyperlipidemia) diagnosed, undiagnosed, treated, and treatment goal in the elderly: Bushehr Elderly Health Program (BEH).BMC endocrine disorders · 2024Article
- Frailty and Parkinson's disease: the role of diabetes mellitus.Frontiers in medicine · 2024Review
- Mediation effect of cognitive impairment for the relationship of type 2 diabetes mellitus with mortality among elderly individuals.Frontiers in endocrinology · 2024Article
- Sociodemographic and Clinical Determinants on Health-Related Quality of Life in Emerging Andalusian Adults with Type 1 Diabetes: A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Insulin resistance drives cognitive impairment in hypertensive pre-diabetic frail elders: the CENTENNIAL study.European journal of preventive cardiology · 2023Article
- Article
- Extended-release metformin improves cognitive impairment in frail older women with hypertension and diabetes: preliminary results from the LEOPARDESS Study.Cardiovascular diabetology · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundDiabetes and hypertension are common in older adults and represent established risk factors for frailty. Frailty is a multidimensional condition due to reserve loss and susceptibility to stressors with a high risk of death, hospitalizations, functional and cognitive impairment. Comorbidities such as diabetes and hypertension play a key role in increasing the risk of mortality, hospitalization, and disability. Moreover, frail patients with diabetes and hypertension are known to have an increased risk of cognitive and physical impairment. Nevertheless, no study assessed the correlation between physical and cognitive impairment in frail older adults with diabetes and hypertension.
methodsWe evaluated consecutive frail older patients with diabetes and hypertension who presented at ASL (local health unit of the Italian Ministry of Health) Avellino, Italy, from March 2021 to October 2021. The inclusion criteria were: a previous diagnosis of diabetes and hypertension with no evidence of secondary causes; age > 65 years; a frailty status; Montreal Cognitive Assessment (MoCA) score < 26.
results179 patients successfully completed the study. We found a strong and significant correlation between MoCA score and 5-m gait speed test (r: 0.877; p < 0.001). To further verify our results, we performed a linear multivariate analysis adjusting for potential confounding factors, with MoCA score as dependent variable, which confirmed the significant association with glycemia (p < 0.001).
conclusionsThis is the first study showing a significant correlation between 5-m gait speed test and MoCA score in frail diabetic and hypertensive older adults.
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