ArticleBMC microbiology2022
Diffusion of OXA-48 carbapenemase among urinary isolates of Klebsiella pneumoniae in non-hospitalized elderly patients.
Article in BMC microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 20 citations in OpenAlex.
- Contrasting In Vitro Activity of Nitroxoline Against Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Characterization ofAntibiotics (Basel, Switzerland) · 2025Article
- Molecular detection of OXA-48 and NDM-1 carbapenemase genes among clinical isolates of Klebsiella pneumoniae recovered from patients attending a private tertiary hospital in Southwestern Nigeria.BMC infectious diseases · 2024Article
- Complete genome sequence of the OXA-48-producingMicrobiology resource announcements · 2024Article
- Bloodstream Infections by AmpC-Producing Enterobacterales: Risk Factors and Therapeutic Outcome.Pathogens (Basel, Switzerland) · 2023Article
- The burden of bacterial antimicrobial resistance in Croatia in 2019: a country-level systematic analysis.Croatian medical journal · 2023Article
- Anti-Klebsiella pneumoniae activity of secondary metabolism of Achromobacter from the intestine of Periplaneta americana.BMC microbiology · 2023Article
- Emergence and Spread of Enterobacterales with Multiple Carbapenemases after COVID-19 Pandemic.Pathogens (Basel, Switzerland) · 2023Article
- Exploring the Antibiotic Resistance Profile of ClinicalAntibiotics (Basel, Switzerland) · 2022Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, a dramatic increase of Klebsiella pneumoniae positive for OXA-48 β-lactamases was observed first in the hospital setting and later in the long-term care facilities (LTCFs) and community in the Zagreb County, particularly, in urinary isolates. The aim of the study was to analyse the epidemiology and the mechanisms of antibiotic resistance of OXA-48 carbapenemase producing K. pneumoniae strains isolated from urine of non-hospitalized elderly patients.
resultsThe isolates were classified into two groups: one originated from the LTCFs and the other from the community. Extended-spectrum β-lactamases (ESBLs) were detected by double disk-synergy (DDST) and combined disk tests in 55% of the isolates (51/92). The ESBL-positive isolates exhibited resistance to expanded-spectrum cephalosporins (ESC) and in majority of cases to gentamicin. LTCFs isolates showed a significantly lower rate of additional ESBLs and consequential resistance to ESC and a lower gentamicin resistance rate compared to the community isolates, similarly to hospital isolates in Zagreb, pointing out to the possible transmission from hospitals.ESBL production was associated with group 1 of CTX-M or SHV-12 β-lactamases. Ertapenem resistance was transferable from only 12 isolates. bla
conclusionsThis study showed eruptive and extensive diffusion of OXA-48 carbapenemase to LTCFs and community population in Zagreb County, particularly affecting patients with UTIs and urinary catheters. On the basis of susceptibility testing, β-lactamase production, conjugation experiments, MLST and plasmid characterization it can be concluded that there was horizontal gene transfer between unrelated isolates, responsible for epidemic spread of OXA-48 carbapenemase in the LTCFs and the community The rapid spread of OXA-48 producing K. pneumoniae points out to the shortcomings in the infection control measures.
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