ArticleThe American journal of hospice & palliative care2022
Incidence of Delirium With Different Oral Opioids in Previously Opioid-Naive Patients.
Article in The American journal of hospice & palliative care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study.BMC medicine · 2026Article
- Comparative effects of fentanyl, morphine, and hydromorphone on postoperative delirium and outcomes after cardiac surgery: a propensity score-matched cohort study.Scientific reports · 2025Article
- Incidence of Delirium during the Initiation Phase of Morphine and Hydromorphone Therapy in Cancer Patients: A Retrospective Comparative Study.The Canadian journal of hospital pharmacy · 2025Article
- A narrative review of neuroprotective effects of remifentanil: from basic research to clinical practice.Frontiers in neurology · 2025Review
- Personalizing Prediction of High Opioid Use in the Neurointensive Care Unit: Development and Validation of a Stratified Risk Model for Acute Brain Injury Due to Stroke or Traumatic Brain Injury.Journal of clinical medicine · 2024Article
- Takotsubo syndrome is triggered by hypoactive delirium and recognized by increased catecholamine requirement in the ICU.Clinics (Sao Paulo, Brazil) · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOpioids are known to induce delirium, but few studies have closely investigated differences in incidence of delirium among different opioids.
objectivesTo determine whether there is a clinically significant difference in the incidence of delirium between oral opioids in previously opioid-naive patients.
methodsSubjects were 259 opioid-naive in-patients with cancer who were started on morphine sulfate, oxycodone hydrochloride, or tapentadol hydrochloride extended-release tablets at our hospital between August 1, 2014, and September 30, 2018. The incidence of delirium during the first week of treatment was compared between the drugs.
resultsThe incidence of delirium was 4.8% (n = 83) for morphine sulfate, 6.9% (n = 131) for oxycodone hydrochloride, and 6.7% (n = 45) for tapentadol hydrochloride. The incidence did not significantly differ between oxycodone hydrochloride (OR = .69, 95% CI = .20-2.30,
conclusionThe incidence of delirium in previously opioid-naive patients did not differ significantly among morphine sulfate, oxycodone hydrochloride, and tapentadol hydrochloride extended-release tablets, suggesting similar risk of delirium in opioid-naive patients among these oral opioids.
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Registered trials
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