ArticleDiabetes & metabolism journal2022
Synergistic Interaction between Hyperuricemia and Abdominal Obesity as a Risk Factor for Metabolic Syndrome Components in Korean Population.
Article in Diabetes & metabolism journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 23 citations in OpenAlex.
- Risk of Ossification of the Posterior Longitudinal Ligament (OPLL) following gout diagnosis: a nationwide cohort study.International orthopaedics · 2026Article
- Clostridium dalinum: A Novel Lactic Acid Bacterium with Excellent Antioxidant and Anti-inflammatory Functions Through NF-κB, Keap1-Nrf2-ARE Signaling Pathways.Probiotics and antimicrobial proteins · 2026Article
- Study on the correlation between hyperuricemia and components of metabolic syndrome in T2DM in China: a single-center, observational study.Frontiers in endocrinology · 2026Observational
- Association of serum uric acid with incident vascular calcification in patients with type 2 diabetes mellitus: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Relative Fat Mass Associated with Hyperuricemia in Adults: A Cross-Sectional Study.Endocrine, metabolic & immune disorders drug targets · 2026Article
- The association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) index and obesity in postmenopausal women: a cross-sectional analysis based on the NHANES.Lipids in health and disease · 2025Article
- Article
- Non-linear association between visceral adipose tissue area and serum uric acid concentration in US adults: findings from NHANES 2011-2018.BMC public health · 2025Article
- Genome Analysis and In Vitro Assay of Probiotic Properties ofMicroorganisms · 2025Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- Association between novel adiposity parameters and hyperuricemia: a cross-sectional study.Frontiers in nutrition · 2025Article
- Development and Validation of a Nomogram for Predicting Hyperuricemia in Perimenopausal Women.International journal of general medicine · 2025Article
- Comparative analysis of three BMI cutoffs for five metabolic abnormalities in the population of Western Guangdong, China.Frontiers in nutrition · 2025Article
- Article
- Prevalence and factors associated with overweight, obesity and central obesity among adults in Shenmu City, Shaanxi Province, China.Preventive medicine reports · 2024Article
- Synergistic interaction between hyperlipidemia and obesity as a risk factor for stress urinary incontinence in Americans.Scientific reports · 2024Article
- Exploring the Relationship Between Different Obesity Metabolism Indices and Hyperuricemia in Patients with Hypertension and Coronary Heart Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Association of resistome abundance with hyperuricaemia in elderly individuals: a metagenomics study.Frontiers in microbiomes · 2024Article
- A predictive model for hyperuricemia among type 2 diabetes mellitus patients in Urumqi, China.BMC public health · 2023Article
- Biodegradation of Uric Acid byMicroorganisms · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study investigated the role of synergistic interaction between hyperuricemia and abdominal obesity as a risk factor for the components of metabolic syndrome.
methodsWe performed a cross-sectional study using the data of 16,094 individuals from the seventh Korean National Health and Nutrition Examination Survey (2016 to 2018). The adjusted odds ratios of metabolic syndrome and its components were analyzed by multivariate logistic regression analysis. The presence of synergistic interaction between hyperuricemia and abdominal obesity was evaluated by calculating the additive scales-the relative excess risk due to interaction, attributable proportion due to interaction, and synergy index (SI).
resultsThere was a synergistic interaction between hyperuricemia and abdominal obesity in hypertriglyceridemia (men: SI, 1.39; 95% confidence interval [CI], 1.01 to 1.98; women: SI, 1.61; 95% CI, 1.02 to 2.69), and low high-density lipoprotein cholesterol (HDL-C) (men: SI, 2.03; 95% CI, 1.41 to 2.91; women: SI, 1.70; 95% CI, 1.05 to 2.95). There was no significant synergistic interaction between hyperuricemia and abdominal obesity for the risk of high blood pressure (men: SI, 1.22; 95% CI, 0.85 to 1.77; women: SI, 1.53; 95% CI, 0.79 to 2.97), and hyperglycemia (men: SI, 1.03; 95% CI, 0.72 to 1.47; women: SI, 1.39; 95% CI, 0.75 to 2.57).
conclusionHyperuricemia and abdominal obesity synergistically increased the risk of hypertriglyceridemia and low HDL-C in both sexes.
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