Evidence map›Paper›PMID 35045587›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2022

Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry.

Linfeng Xu, Xiangpeng Li, Wenzong Li, Kai-Chun Chang, Hyunjun Yang, Nannan Tao, Pengfei Zhang, Emory M Payne, Cyrus Modavi, Jacqueline Humphries and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Linfeng XuDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.ORCID https://orcid.org/0000-0002-6386-1815
Xiangpeng LiDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
Wenzong LiAmyris Inc., 5885 Hollis St #100, Emeryville, CA, 94608, USA.
Kai-Chun ChangDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
Hyunjun YangInstitute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, USA.
Nannan TaoBruker Nano Surfaces, San Jose, CA, 95134, USA.
Pengfei ZhangDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
Emory M PayneDepartment of Chemistry, University of Michigan, Ann Arbor, MI, 48104, USA.ORCID https://orcid.org/0000-0002-5956-8392
Cyrus ModaviDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
Jacqueline HumphriesAmyris Inc., 5885 Hollis St #100, Emeryville, CA, 94608, USA.
Chia-Wei LuAmyris Inc., 5885 Hollis St #100, Emeryville, CA, 94608, USA.
Adam R AbateDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.ORCID https://orcid.org/0000-0001-9614-4831

Funding

Gigapixel digital PCR in Giant Unilamellar VesiclesR01EB019453 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R., CHIU, CHARLES YEN · 2014 to 2022
$3.9M
Accurate and unbiased single cell sequencing with digital droplet MDAR01HG008978 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABATE, ADAM R. · 2016 to 2018
$1.9M
CDC HHS BAA 75D301-19-R-67835 (Topic #6)Chan Zuckerberg Biohub, the National Institutes of Health (NIH) R01-EB019453-02Chan Zuckerberg Biohub, the National Institutes of Health (NIH) R01-HG008978-01NHGRI NIH HHS R01 HG008978NIBIB NIH HHS R01 EB019453Office of the Director of National Intelligence (ODNI) N66001-18-C-4507United States Department of Defense, Defense Advanced Research Projects Agency (DARPA) W911NF1920013Virology Surveillance and Diagnosis Branch, Influenza Division
6 · The paper itself

Abstract

Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer-scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell-based assays.

Indexed as

LasersLightSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionizationmass spectrometry imagingmicrobowlsmicrowell arrays

Identifiers

PMID35045587
PMCPMC9028217

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.