ArticleNature2022
The cGAS-STING pathway drives type I IFN immunopathology in COVID-19.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 351 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
351citing papers in PubMed, 1 pooled it
43.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
351 citing papers in PubMed, 1 synthesis or guideline pooled it, 526 citations in OpenAlex.
- Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025Pooled it
- Intermittent fasting and a no-sugar diet for Long COVID symptoms: a randomized crossover trial.Scientific reports · 2025Trial
- A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-α, enhancing antiviral defense and exacerbating autoimmunity.American journal of human genetics · 2026Article
- The cGAS-STING/MITA pathway in innate antiviral immunity and beyond.Cell insight · 2026Review
- Metabolic stress-activated endothelial STING rewires the sinusoidal immune niche to promote MASLD progression.The Journal of clinical investigation · 2026Article
- The bidirectional immunoregulatory effects of Traditional Chinese Medicine on the cGAS-STING signaling pathway and their translational prospects.Chinese medicine · 2026Review
- The cGAS-STING Pathway: A Double-Edged Regulator of Neuroinflammation and Myelin Regeneration.Molecular neurobiology · 2026Review
- cGAS-STING axis: A central regulator of neural homeostasis and neuroinflammatory pathogenesis.Neural regeneration research · 2026Article
- Article
- Spike 1 protein of SARS-CoV-2 induces endothelial inflammation and vascular dysfunction through interferon ISG15-dependent mechanisms.Cardiovascular research · 2026Article
- Co-exposure to cannabinoids and nicotine increases senescence in prenatal human lung development.Pediatric research · 2026Article
- Therapeutic targeting of the cGAS-STING pathway in human disease.The Journal of clinical investigation · 2026Review
- The modulation of AUF1 regulates the R-loop resolution activating the immune response in DDR.iScience · 2026Article
- Carfilzomib Induces Cardiotoxicity by Blocking Autophagic Flux Through the cGAS-STING Signaling Pathway.Biomolecules · 2026Article
- A Decade of cGAS Discovery: Point of Convergence in Oral Diseases.International dental journal · 2026Review
- Respiratory Organ-on-a-Chip for Disease Modeling: From Architecture to Functional Integration.Advanced healthcare materials · 2026Review
- Senescence-like cells recruit γδ T cells to drive prolonged hyposmia after SARS-CoV-2 infection in mice.EMBO reports · 2026Article
- An immune-competent lung-on-a-chip for modelling the human severe influenza infection response.Nature biomedical engineering · 2026Article
- Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress.Cell communication and signaling : CCS · 2026Article
- Targeting VDAC1 to protect against mitochondria-linked cell death pathways: apoptosis, pyroptosis, ferroptosis, and associated diseases.Apoptosis : an international journal on programmed cell death · 2026Article
291 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 2 countries.
Jeremy Di Domizio *Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6281-3918
Muhammet F Gulen *Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Fanny Saidoune *Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
Vivek V Thacker *Global Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-1681-627X
Ahmad Yatim *Department of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
Kunal SharmaGlobal Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8086-3436
Théo NassGlobal Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-5934-2895
Emmanuella GuenovaDepartment of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-5478-8735
Martin SchallerUniversity Department of Dermatology, Eberhard Karls University of Tübingen, Tübingen, Germany.
Curdin ConradDepartment of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-2547-3440
Christine GoepfertInstitute of Animal Pathology, COMPATH, University of Bern, Bern, Switzerland.
Laurence de LevalInstitute of Pathology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-3994-516X
Christophe von GarnierDivision of Pulmonology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
Sabina BerezowskaInstitute of Pathology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland.
Anaëlle DuboisBiological Electron Microscopy Facility, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-1260-9123
Michel GillietDepartment of Dermatology, CHUV University Hospital and University of Lausanne (UNIL), Lausanne, Switzerland. michel.gilliet@chuv.ch.ORCID http://orcid.org/0000-0002-4609-3762
Andrea AblasserGlobal Health Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland. andrea.ablasser@epfl.ch.ORCID http://orcid.org/0000-0002-8475-8999
University of Lausanne · CHÉcole Polytechnique Fédérale de Lausanne · CHUniversity Hospital of Lausanne · CHUniversity of Bern · CHUniversity of Tübingen · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications
Indexed as
AnimalsCells, CulturedCOVID-19Cyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDisease Models, AnimalDisease ProgressionDNA, MitochondrialEndothelial CellsFemaleGene Expression RegulationHumansImmunity, InnateInterferon Type ILungMacrophagesMembrane ProteinscGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNA, MitochondrialInterferon Type IMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSting1 protein, mouseSTING Protein
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.