ArticleNeuron2022
Acute restraint stress redirects prefrontal cortex circuit function through mGlu
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Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed.
- Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility.Neuron · 2026Article
- Repeated restraint stress enhances visual plasticity through locus coeruleus (LC)-V1 projection in adult mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- From Efference Copy to Emotional State: Insular Cortex Somatostatin Neurons Buffer Adaptive Responses to Physical Stress.Biological psychiatry global open science · 2026Article
- Insular Somatostatin Interneurons Are Targeted by Motor Cortex Efferents and Modulate Affective States.Biological psychiatry global open science · 2026Article
- Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets.Cell · 2026Article
- Respiratory-Limbic Coupling via a Thalamic Circuit Alleviates Anxiety.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Short-term high-altitude exposure protects working memory by balancing intestinal microbiota.BMC microbiology · 2026Article
- Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner.Addiction neuroscience · 2025Article
- The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action.Nature communications · 2025Article
- Maladaptive Neuroplasticity Under Stress: Insights into Neuronal and Synaptic Changes in the Prefrontal Cortex.Molecular neurobiology · 2025Review
- Single-cell transcriptomics reveals Sox6 positive interneurons enriched in the prefrontal cortex of female mice vulnerable to chronic social stress.Molecular psychiatry · 2025Article
- Ketamine-induced static and dynamic functional connectivity changes are modulated by opioid receptors and biological sex in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens.Nature communications · 2025Article
- Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure.Molecular psychiatry · 2025Article
- Neuropeptidergic transmission shapes emergent properties of prefrontal cortical circuits underlying learning.bioRxiv : the preprint server for biology · 2025Article
- Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure.Molecular psychiatry · 2025Article
- Increased mGluR5 in somatostatin-positive interneurons mediates deactivation of the mPFC in a mouse model of neuropathic pain.Experimental & molecular medicine · 2025Article
- Somatostatin-expressing interneurons of prefrontal cortex modulate social deficits in the Magel2 mouse model of autism.Molecular autism · 2025Article
- Neocortical somatostatin neuron diversity in cognition and learning.Trends in neurosciences · 2025Review
Corrections and comments
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Authors and funding
20 authors.
Max E JoffeDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15219, USA; Translational Neuroscience Program, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: joffeme@upmc.edu.
James MaksymetzDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Warren Center for Neuroscience Drug Discovery, Nashville, TN, USA; Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA.
Joseph R LuschingerVanderbilt Center for Addiction Research, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Shalini DograDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Warren Center for Neuroscience Drug Discovery, Nashville, TN, USA.
Anthony S FerrantiDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Warren Center for Neuroscience Drug Discovery, Nashville, TN, USA.
Deborah J LuessenDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Warren Center for Neuroscience Drug Discovery, Nashville, TN, USA.
Isabel M GallingerDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Warren Center for Neuroscience Drug Discovery, Nashville, TN, USA.
Zixiu XiangDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Warren Center for Neuroscience Drug Discovery, Nashville, TN, USA.
Hannah BranthwaiteDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Patrick R MeluginDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Kellie M WillifordDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Nashville, TN, USA.
Samuel W CentanniVanderbilt Center for Addiction Research, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Brenda C ShieldsDepartment of Neurobiology, Duke University, Durham, NC 27708, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Craig W LindsleyDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Warren Center for Neuroscience Drug Discovery, Nashville, TN, USA; Vanderbilt Center for Addiction Research, Nashville, TN, USA; Department of Chemistry, Vanderbilt University, Nashville, TN, USA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.
Erin S CalipariDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Cody A SicilianoDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Colleen M NiswenderDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Warren Center for Neuroscience Drug Discovery, Nashville, TN, USA; Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael R TadrossDepartment of Neurobiology, Duke University, Durham, NC 27708, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Danny G WinderDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Nashville, TN, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
P Jeffrey ConnDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA; Warren Center for Neuroscience Drug Discovery, Nashville, TN, USA; Vanderbilt Center for Addiction Research, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: jeff.conn@vanderbilt.edu.
Funding
REGULATION OF SIGNALING BY MGLUR5R01MH062646 · NIMH · VANDERBILT UNIVERSITY · PI P Jeffrey Conn, COLLEEN M NISWENDER · 2001 to 2026
$10.9MOverall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3MFUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPESR01NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 1993 to 2025
$6.2MSex Dependent Recruitment of PKCdelta Neurons by Stress: Administrative Supplement for Noradrenergic Regulation in the BNSTR01DA042475 · NIDA · VANDERBILT UNIVERSITY · PI WINDER, DANNY G. · 2016 to 2025
$4.0MAlcohol action on extended amygdala glutamate synapsesR37AA019455 · NIAAA · VANDERBILT UNIVERSITY · PI WINDER, DANNY G. · 2015 to 2024
$3.9MDART2.0: comprehensive cell type-specific behavioral neuropharmacologyRF1MH117055 · NIMH · DUKE UNIVERSITY · PI TADROSS, MICHAEL R · 2018 to 2018
$3.8MFunctions of Metabotropic Glutamate Receptor SubtypesR37NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2014 to 2020
$3.5MInterrogating dynamics of whole-brain volumes with cell type-specific pharmacologyDP2MH119425 · NIMH · DUKE UNIVERSITY · PI TADROSS, MICHAEL R · 2018 to 2018
$2.4MMaking and breaking opioid memories to prevent relapseDP1DA048931 · NIDA · VANDERBILT UNIVERSITY · PI CALIPARI, ERIN · 2019 to 2023
$2.4MMesocortical neuromodulation in punishment-resistant alcohol drinkingR01AA030115 · NIAAA · VANDERBILT UNIVERSITY · PI Cody Siciliano · 2022 to 2026
$2.1M8/8: INIA Stress and Chronic Alcohol Interactions: Cross-species plasticity signatures of alcohol and stressU01AA029971 · NIAAA · VANDERBILT UNIVERSITY · PI Cody Siciliano · 2022 to 2026
$2.0MAlcohol action on extended amygdala glutamate synapsesR01AA019455 · NIAAA · VANDERBILT UNIVERSITY · PI WINDER, DANNY G. · 2010 to 2014
$1.8MNIAAA NIH HHS F30 AA027126NIAAA NIH HHS K99 AA027806NIAAA NIH HHS R00 AA027806NIAAA NIH HHS R01 AA019455NIAAA NIH HHS R01 AA030115NIAAA NIH HHS R37 AA019455NIAAA NIH HHS U01 AA029971NICHD NIH HHS P50 HD103537NIDA NIH HHS DP1 DA048931NIDA NIH HHS R00 DA042111NIDA NIH HHS R00 DA045103NIDA NIH HHS R01 DA042475NIMH NIH HHS DP2 MH119425NIMH NIH HHS R01 MH062646NIMH NIH HHS RF1 MH117055NINDS NIH HHS R01 NS031373NINDS NIH HHS R37 NS031373
Abstract
Inhibitory interneurons orchestrate prefrontal cortex (PFC) activity, but we have a limited understanding of the molecular and experience-dependent mechanisms that regulate synaptic plasticity across PFC microcircuits. We discovered that mGlu
Indexed as
InterneuronsSomatostatinAnimalsLong-Term PotentiationMiceNeuronal PlasticityPrefrontal CortexSynapsesSomatostatinantidepressantCa(2+)-permeable AMPA receptorDARTGABAGluA2-lacking AMPA receptorGPCRmetabotropic glutamate receptormotivationoptogeneticsworking memory
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.