ArticleToxicology and applied pharmacology2022
Environmental exposure to volatile organic compounds is associated with endothelial injury.
Article in Toxicology and applied pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Advances in biomarkers of benzene exposure and toxicity: From mechanistic insights to occupational health applications (Review).Molecular medicine reports · 2026Review
- Associations between volatile organic compound mixtures and allostatic load: Evidence from the Green Heart Louisville Project.Environmental research · 2026Article
- A unified liquid chromatography-mass spectrometric approach combining targeted and untargeted analyses for community exposure profiling in wastewater.Environment international · 2026Article
- The Green Heart Project: objectives, design, and methods.American journal of epidemiology · 2026Article
- A Population-Centered Health Framework for Analyzing Superfund Sites With a History of Volatile Organic Compound Contamination.Community health equity research & policy · 2026Article
- Associations of sympathetic activation with exposure to volatile organic compounds: A cross-sectional study.Environmental research · 2025Article
- Blood concentrations of volatile organic compounds and hypertension in the GuLF Study.The Science of the total environment · 2025Article
- Internal Exposure to BTEX in Tropical Children: Does Exposure Speed Up Pubertal Development?Antioxidants (Basel, Switzerland) · 2025Article
- Benzene metabolites increase vascular permeability by activating heat shock proteins and Rho GTPases.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Secure and Trusted Crowdsensing for Outdoor Air Quality Monitoring: State of the Art and Perspectives.Sensors (Basel, Switzerland) · 2025Review
- Volatile organic compound exposure is associated with hyperuricemia in the general population: an analysis of 6878 adults from the NHANES.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Simultaneous profiling of mercapturic acids, glucuronic acids, and sulfates in human urine.Environment international · 2025Article
- Urinary metabolomics reveals myo-inositol and (E)-Monocrotophos associate with prognosis in ACS comorbid with T2DM and preserved renal function.Scientific reports · 2025Article
- Association between exposure to volatile organic compounds and atherogenic index of plasma in NHANES 2011-2018.Scientific reports · 2025Article
- Association between volatile organic compounds exposure and cardiometabolic function: a population-based study.Frontiers in public health · 2025Article
- Independent and combined associations of VOCs exposure and MetS in theFrontiers in public health · 2025Article
- Clustering analysis of volatile organic compound biomarkers with tobacco exposure and the association with cardiovascular health outcomes in an observation study cohort.Tobacco induced diseases · 2025Article
- Association between urinary volatile organic compounds metabolites and rheumatoid arthritis among the adults from NHANES 2011-2018.Scientific reports · 2024Article
- Volatile organic compounds exposure in relation to glucose homeostasis and type 2 diabetes in older adults from the NHANES.Scientific reports · 2024Article
- Exploring the impact of occupational exposure: A study on cardiovascular autonomic functions of male gas station attendants in Sri Lanka.Physiological reports · 2024Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveVolatile organic compounds (VOCs) are airborne toxicants abundant in outdoor and indoor air. High levels of VOCs are also present at various Superfund and other hazardous waste sites; however, little is known about the cardiovascular effects of VOCs. We hypothesized that ambient exposure to VOCs exacerbate cardiovascular disease (CVD) risk by depleting circulating angiogenic cells (CACs). APPROACH AND
resultsIn this cross-sectional study, we recruited 603 participants with low-to-high CVD risk and measured 15 subpopulations of CACs by flow cytometry and 16 urinary metabolites of 12 VOCs by LC/MS/MS. Associations between CAC and VOC metabolite levels were examined using generalized linear models in the total sample, and separately in non-smokers. In single pollutant models, metabolites of ethylbenzene/styrene and xylene, were negatively associated with CAC levels in both the total sample, and in non-smokers. The metabolite of acrylonitrile was negatively associated with CD45
conclusionLow-level ambient exposure to VOCs is associated with CAC depletion, which could compromise endothelial repair and angiogenesis, and exacerbate CVD risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.