Evidence map›Paper›PMID 35045287›Full record

ArticleCell reports2022

Lipid droplet dynamics regulate adult muscle stem cell fate.

Feng Yue, Stephanie N Oprescu, Jiamin Qiu, Lijie Gu, Lijia Zhang, Jingjuan Chen, Naagarajan Narayanan, Meng Deng, Shihuan Kuang

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
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  12. Deuterated Polyunsaturated Fatty Acids AlleviatebioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. AAV9-mediated gene supplementation therapy prevents and rescues arrhythmogenic cardiomyopathy in Pnpla2-mutated mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  16. Review
  17. Lipid droplets as cell fate determinants in skeletal muscle.Trends in endocrinology and metabolism: TEM · 2025
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Feng YueDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA. Electronic address: fyue@purdue.edu.
Stephanie N OprescuDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Jiamin QiuDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Lijie GuDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Lijia ZhangDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Jingjuan ChenDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Naagarajan NarayananDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.
Meng DengDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN 47907, USA.
Shihuan KuangDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA. Electronic address: skuang@purdue.edu.
Purdue University West Lafayette · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
Immunomyoblasts in muscle regenerationR01AR078695 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2021 to 2025
$2.2M
Metabolic regulation of muscle satellite cell homeostasisR01DK132819 · NIDDK · PURDUE UNIVERSITY · PI Shihuan Kuang · 2023 to 2026
$2.0M
PTEN Function in Satellite CellsR01AR071649 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2017 to 2021
$1.7M
BD Fortessa Flow Cytometer for Multi-User Shared FacilityS10OD020029 · OD · PURDUE UNIVERSITY · PI RATLIFF, TIMOTHY L. · 2015 to 2015
$412k
Engineering A Biomaterial Niche of Satellite Cells for Skeletal Muscle RegenerationR03AR068108 · NIAMS · PURDUE UNIVERSITY · PI DENG, MENG · 2016 to 2018
$227k
Sox11 function in muscle stem cellsF31AR077424 · NIAMS · PURDUE UNIVERSITY · PI OPRESCU, STEPHANIE NICOLE · 2020 to 2022
$114k
NCI NIH HHS P30 CA023168NIAMS NIH HHS F31 AR077424NIAMS NIH HHS R01 AR071649NIAMS NIH HHS R01 AR078695NIAMS NIH HHS R03 AR068108NIDDK NIH HHS R01 DK132819NIH HHS S10 OD020029
6 · The paper itself

Abstract

The lipid droplet (LD) is a central hub for fatty acid metabolism in cells. Here we define the dynamics and explore the role of LDs in skeletal muscle satellite cells (SCs), a stem cell population responsible for muscle regeneration. In newly divided SCs, LDs are unequally distributed in sister cells exhibiting asymmetric cell fates, as the LD

Indexed as

AnimalsLipid DropletsMiceMuscle DevelopmentMuscle, SkeletalRegenerationSatellite Cells, Skeletal Muscleasymmetric divisionATGLmetabolismmuscle satellite celloxidative stressregenerationself-renewal

Identifiers

PMID35045287
PMCPMC9127130
OpenAlexW4206407082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.