Evidence map›Paper›PMID 35045279›Full record

ArticleCell reports2022

Presynaptic mechanisms underlying GABA

Baris Alten, Natalie J Guzikowski, Zack Zurawski, Heidi E Hamm, Ege T Kavalali

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. GABAExperimental physiology · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Synaptic vesicle pool heterogeneity drives an anomalous form of synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. GABAProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
  11. Review
  12. Tonic activation of GABAFrontiers in synaptic neuroscience · 2023
    Article
  13. SNAP25 differentially contributes to GFrontiers in cellular neuroscience · 2023
    Article
  14. Article
  15. Reduced CaFrontiers in neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Baris AltenDepartment of Pharmacology, Vanderbilt University, 7130A MRB III 465 21(st) Avenue South, Nashville, TN 37240-7933, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240-7933, USA.
Natalie J GuzikowskiDepartment of Pharmacology, Vanderbilt University, 7130A MRB III 465 21(st) Avenue South, Nashville, TN 37240-7933, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240-7933, USA.
Zack ZurawskiDepartment of Pharmacology, Vanderbilt University, 7130A MRB III 465 21(st) Avenue South, Nashville, TN 37240-7933, USA.
Heidi E HammDepartment of Pharmacology, Vanderbilt University, 7130A MRB III 465 21(st) Avenue South, Nashville, TN 37240-7933, USA.
Ege T KavalaliDepartment of Pharmacology, Vanderbilt University, 7130A MRB III 465 21(st) Avenue South, Nashville, TN 37240-7933, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240-7933, USA. Electronic address: ege.kavalali@vanderbilt.edu.
Vanderbilt University · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Role of SNARE Interactions in Central Synapse FunctionR01MH066198 · NIMH · VANDERBILT UNIVERSITY · PI KAVALALI, EGE T · 2004 to 2023
$7.9M
G PROTEIN STRUCTURE/FUNCTIONR01EY010291 · NEI · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E · 1994 to 2010
$3.9M
Calcium signaling and synaptic maintenance in Alzheimers diseaseRF1AG055577 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI BEZPROZVANNY, ILYA B, KAVALALI, EGE T · 2017 to 2017
$3.0M
Regulation of exocytosis by direct Gbg blockade of fusionR01NS111749 · NINDS · VANDERBILT UNIVERSITY · PI ALFORD, SIMON T, HAMM, HEIDI E · 2019 to 2023
$2.0M
GPCR Regulation of insulin secretion by modulation of the release machineryR01DK109204 · NIDDK · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E · 2016 to 2019
$1.4M
NEI NIH HHS R01 EY010291NIA NIH HHS RF1 AG055577NICHD NIH HHS P50 HD103537NIDDK NIH HHS R01 DK109204NIMH NIH HHS R01 MH066198NINDS NIH HHS R01 NS111749
6 · The paper itself

Abstract

Inhibition of neurotransmitter release by neurotransmitter substances constitutes a fundamental means of neuromodulation. In contrast to well-delineated mechanisms that underlie inhibition of evoked release via suppression of voltage-gated Ca

Indexed as

AnimalsFemalegamma-Aminobutyric AcidGlutamic AcidMaleNeurotransmitter AgentsPresynaptic TerminalsRatsRats, Sprague-DawleyReceptors, GABA-BSynaptic Transmissiongamma-Aminobutyric AcidGlutamic AcidNeurotransmitter AgentsReceptors, GABA-BGABAGPCRGβγinhibitionmetabotropicneurotransmitterregulationSNAP25SNAREspontaneous release

Identifiers

PMID35045279
PMCPMC8793855
OpenAlexW4205816402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.