ArticleJournal of applied clinical medical physics2022
Dosimetric advantages of daily adaptive strategy in IMPT for high-risk prostate cancer.
Article in Journal of applied clinical medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- Clinical Comparison of Beam-Specific Planning Target Volume Single-Field Uniform Dose and Robust Intensity-Modulated Proton Therapy in Ultra-Hypofractionation for Prostate Cancer.International journal of particle therapy · 2026Article
- Nominal plan robustness may predict plan degradation in proton therapy for oropharyngeal head-and-neck cancer.Journal of applied clinical medical physics · 2026Article
- Retrospective analysis of adaptation frequencies and factors in offline in offline adaptive proton therapy.Journal of applied clinical medical physics · 2026Article
- Interfractional body surface monitoring using daily cone-beam computed tomography imaging for pediatric adaptive proton therapy.Physics and imaging in radiation oncology · 2025Article
- Dosimetric advantages of daily adaptive strategy in IMPT for high-risk prostate cancer.Journal of applied clinical medical physics · 2022Article
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the dosimetric advantages of daily adaptive radiotherapy (DART) in intensity-modulated proton therapy (IMPT) for high-risk prostate cancer by comparing estimated doses of the conventional non-adaptive radiotherapy (NART) that irradiates according to an original treatment plan through the entire treatment and the DART that uses an adaptive treatment plan generated by using daily CT images acquired before each treatment.
methodsTwenty-three patients with prostate cancer were included. A treatment plan with 63 Gy (relative biological effectiveness (RBE)) in 21 fractions was generated using treatment planning computed tomography (CT) images assuming that all patients had high-risk prostate cancer for which the clinical target volume (CTV) needs to include prostate and the seminal vesicle (SV) in our treatment protocol. Twenty-one adaptive treatment plans for each patient (total 483 data sets) were generated using daily CT images, and dose distributions were calculated. Using a 3 mm set-up uncertainty in the robust optimization, the doses to the CTV, prostate, SV, rectum, and bladder were compared.
resultsEstimated accumulated doses of NART and DART in the 23 patients were 60.81 ± 3.47 Gy (RBE) and 63.24 ± 1.04 Gy (RBE) for CTV D99 (p < 0.01), 62.99 ± 1.28 Gy (RBE) and 63.43 ± 1.33 Gy (RBE) for the prostate D99 (p = 0.2529), and 59.07 ± 5.19 Gy (RBE) and 63.17 ± 1.04 Gy (RBE) for SV D99 (p < 0.001). No significant differences were observed between NART and DART in the estimated accumulated dose for the rectum and bladder.
conclusionCompared with the NART, DART was shown to be a useful approach that can maintain the dose coverage to the target without increasing the dose to the organs at risk (OAR) using the 3 mm set-up uncertainty in the robust optimization in patients with high-risk prostate cancer.
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