ArticleScience advances2022
An estrogen-sensitive hypothalamus-midbrain neural circuit controls thermogenesis and physical activity.
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Ablation of microglial estrogen receptor alpha predisposes male mice to diet-induced obesity.Metabolism: clinical and experimental · 2026Article
- Diosgenin activates ERα-dependent PI3K/AKT/GSK3β signaling to enhance brain-derived serotonin and alleviate postmenopausal bone loss.Journal of advanced research · 2026Article
- Hypothalamic actions of estrogens in the regulation of energy and glucose homeostasis.Reviews in endocrine & metabolic disorders · 2026Review
- Regulation of physical activity and energy expenditure through Phf6 in the medial preoptic area.Nature communications · 2026Article
- GLP-1 Release by Rare Sugar D-Allulose Ameliorates Sucrose-Induced Obesity and Glucose Intolerance in Ovariectomized Mice.International journal of molecular sciences · 2026Article
- Review
- Alterations in whole-brain white matter structural network among females with abdominal obesity by appetite subtypes.Frontiers in nutrition · 2026Article
- PI3K in the VMH Attenuates Diet-Induced Obesity and Participates in the Effects of E2 on Energy Expenditure in Mice.Journal of the Endocrine Society · 2025Article
- Amino Acid-Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic manner.bioRxiv : the preprint server for biology · 2025Article
- Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice.Nature metabolism · 2025Article
- Vestibular neurons link motion sickness, behavioural thermoregulation and metabolic balance in mice.Nature metabolism · 2025Article
- Targeting the central and peripheral nervous system to regulate bone homeostasis: mechanisms and potential therapies.Military Medical Research · 2025Review
- Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females.Molecular metabolism · 2025Article
- Deep Learning-Based Ion Channel Kinetics Analysis for Automated Patch Clamp Recording.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons.Science advances · 2024Article
- 27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior.Science advances · 2024Article
- Lateral Habenula Neurons Signal Cold Aversion and Participate in Cold Aversion.Neurochemical research · 2024Article
- Estrogen signaling in the dorsal raphe regulates binge-like drinking in mice.Translational psychiatry · 2024Article
- Advanced neurobiological tools to interrogate metabolism.Nature reviews. Endocrinology · 2023Review
Corrections and comments
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Authors and funding
25 authors at 5 institutions in 1 country.
Hui YeDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-8473-0603
Bing FengPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA.
Chunmei WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-8104-6892
Kenji SaitoChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-6464-4401
Yongjie YangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Lucas IbrahimiDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-8122-5305
Sarah SchaulDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-9951-7733
Nirali PatelDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-1400-4398
Leslie SaenzDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Pei LuoDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-8983-9229
Penghua LaiDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-6119-8194
Valeria TorresDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-6976-9673
Maya KotaDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-9060-3643
Devin DixitDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-9591-2173
Xing CaiChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Na QuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-6267-6047
Ilirjana HyseniChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-4425-6027
Kaifan YuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-5018-3744
Yuwei JiangDepartment of Physiology and Biophysics, The University of Illinois at Chicago, Chicago, IL 60612, USA.
Qingchun TongBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0002-4561-2540
Zheng SunDepartment of Internal Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-6858-0633
Benjamin R ArenkielDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Yanlin HePennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA.ORCID 0000-0002-5471-9016
Pingwen XuDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-9363-4114
Yong XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-4908-1572
University of Illinois Chicago · USChildren's Nutrition Research Center at Baylor College of Medicine · USBaylor College of Medicine · USPennington Biomedical Research Center · USBrown Foundation · US
Funding
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5MTRANSGENIC COREP60DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI BELL, GRAEME I · 1985 to 2012
$25.5MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9MThe role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Jacqueline M Stephens · 2020 to 2026
$18.4MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MProject 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythmsP01DK113954 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI O'MALLEY, BERT W · 2018 to 2022
$7.9MSteps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8MZebrafish CoreU54NS093793 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2015 to 2022
$7.5MR01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4MMouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2MMAPPING CONNECTIVITY ONTO POSTNATAL-BORN NEURONSR01NS078294 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ARENKIEL, BENJAMIN R · 2012 to 2023
$3.6MAlcohol Research Training in epigenetics and pathophysiology (ARTEP)T32AA026577 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SUBHASH C. PANDEY · 2019 to 2026
$2.7MNHLBI NIH HHS R01 HL153320NIAAA NIH HHS T32 AA026577NIA NIH HHS R03 AG070687NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NICHD NIH HHS U54 HD090255NIDDK NIH HHS K01 DK111771NIDDK NIH HHS K01 DK119471NIDDK NIH HHS P01 DK113954NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK072476NIDDK NIH HHS P60 DK020595NIDDK NIH HHS R00 DK107008NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK111436NIDDK NIH HHS R01 DK114279NIDDK NIH HHS R01 DK115761NIDDK NIH HHS R01 DK117281NIDDK NIH HHS R01 DK120858NIDDK NIH HHS R01 DK123098NIDDK NIH HHS R01 DK125480NIEHS NIH HHS R01 ES027544NIGMS NIH HHS P20 GM135002NINDS NIH HHS R21 NS108091NINDS NIH HHS U54 NS093793
Abstract
Estrogen receptor–α (ERα) expressed by neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus (ERα
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.