ArticleScience translational medicine2022
Human brain mapping with multithousand-channel PtNRGrids resolves spatiotemporal dynamics.
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 123 citations in OpenAlex.
- A soft bioelectronic system with a responsive hydrogel neural interface for direct force quantification and real-time intraoperative craniocerebral injury monitoring.Nature biomedical engineering · 2026Article
- High-channel-count neural recording and stimulation platform with 5376 simultaneous recording channels.npj biomedical innovations · 2026Article
- A Thin Film Transistor Backplane for Scalable Chronic Neural Interfaces.bioRxiv : the preprint server for biology · 2026Article
- Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation.Nature biomedical engineering · 2026Article
- High-resolution brain-computer interface with electrode scalability and minimally invasive surgery.Nature biomedical engineering · 2026Article
- Size Scaling of the Electrochemical Performance of TiSmall (Weinheim an der Bergstrasse, Germany) · 2026Article
- Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cortical spreading depolarizations in stroke: Mechanisms, neuroprotective interventions, and monitoring techniques.GeroScience · 2026Review
- Size Scaling of the Electrochemical Performance of TibioRxiv : the preprint server for biology · 2026Article
- A soft electrode array with reconfigurable hydrogel interfaces for high-fidelity neurophysiological monitoring during craniotomy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- High-channel-count neural recording and stimulation platform with 5,376 simultaneous recording channels.bioRxiv : the preprint server for biology · 2026Article
- Conformal bumped electrode web for chronic ECoG recordings in swine.Microsystems & nanoengineering · 2026Article
- Testing circuit-level theories of consciousness in humans.Trends in cognitive sciences · 2026Review
- Two-dimensional semiconductor-based active array for high-fidelity spatiotemporal monitoring of neural activities.Nature materials · 2026Article
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Deciphering Neural Mechanisms Underlying Marmoset Dynamic Natural Behaviors Using a Miniaturized Wireless Large-Scale Coverage Neural Recorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A wireless subdural-contained brain-computer interface with 65,536 electrodes and 1,024 channels.Nature electronics · 2025Article
- Long-Term Stable Subdural Recordings Enabled by Fibrosis-Resistant Hydrogel-Integrated µECoG Arrays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 1 country.
Funding
Abstract
Electrophysiological devices are critical for mapping eloquent and diseased brain regions and for therapeutic neuromodulation in clinical settings and are extensively used for research in brain-machine interfaces. However, the existing clinical and experimental devices are often limited in either spatial resolution or cortical coverage. Here, we developed scalable manufacturing processes with a dense electrical connection scheme to achieve reconfigurable thin-film, multithousand-channel neurophysiological recording grids using platinum nanorods (PtNRGrids). With PtNRGrids, we have achieved a multithousand-channel array of small (30 μm) contacts with low impedance, providing high spatial and temporal resolution over a large cortical area. We demonstrated that PtNRGrids can resolve submillimeter functional organization of the barrel cortex in anesthetized rats that captured the tissue structure. In the clinical setting, PtNRGrids resolved fine, complex temporal dynamics from the cortical surface in an awake human patient performing grasping tasks. In addition, the PtNRGrids identified the spatial spread and dynamics of epileptic discharges in a patient undergoing epilepsy surgery at 1-mm spatial resolution, including activity induced by direct electrical stimulation. Collectively, these findings demonstrated the power of the PtNRGrids to transform clinical mapping and research with brain-machine interfaces.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.