Evidence map›Paper›PMID 35044775›Full record

ArticleJournal of medicinal chemistry2022

In Vitro and In Vivo Inhibition of the

Samantha Ottavi, Sarah M Scarry, John Mosior, Yan Ling, Julia Roberts, Amrita Singh, David Zhang, Laurent Goullieux, Christine Roubert, Eric Bacqué and 13 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Targeting Siderophore Biosynthesis to Thwart Microbial Growth.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Unlocking Opportunities forACS infectious diseases · 2024
    Review
  6. Review
  7. Article
  8. ACS medicinal chemistry letters · 2023
    Article
  9. Unraveling the mechanisms of intrinsic drug resistance inFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 1 country.

Samantha OttaviDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Sarah M ScarryDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
John MosiorDepartments of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, Texas 77843, United States.
Yan LingDepartment of Microbiology & Immunology, Weill Cornell Medicine, New York, New York 10065, United States.
Julia RobertsDepartment of Microbiology & Immunology, Weill Cornell Medicine, New York, New York 10065, United States.
Amrita SinghDepartment of Microbiology & Immunology, Weill Cornell Medicine, New York, New York 10065, United States.
David ZhangDepartment of Microbiology & Immunology, Weill Cornell Medicine, New York, New York 10065, United States.
Laurent GoullieuxEvotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.
Christine RoubertEvotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.
Eric BacquéEvotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.
H Rachel LagiakosSchrödinger, Inc., 120 W. 45 Street, New York, New York 10036, United States.
Jeremie VendomeSchrödinger, Inc., 120 W. 45 Street, New York, New York 10036, United States.
Francesca MoracaSchrödinger, Inc., 120 W. 45 Street, New York, New York 10036, United States.ORCID 0000-0003-0248-9834
Kelin LiDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Andrew J PerkowskiDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Remya RameshDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Matthew M BowlerDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
William TracyDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Victoria A FeherSchrödinger, Inc., 120 W. 45 Street, New York, New York 10036, United States.
James C SacchettiniDepartments of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, Texas 77843, United States.ORCID 0000-0001-5767-2367
Ben S GoldDepartment of Microbiology & Immunology, Weill Cornell Medicine, New York, New York 10065, United States.ORCID 0000-0002-9562-8241
Carl F NathanDepartment of Microbiology & Immunology, Weill Cornell Medicine, New York, New York 10065, United States.
Jeffrey AubéDivision of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID 0000-0003-1049-5767
University of North Carolina at Chapel Hill · USCornell University · USSchrodinger (United States) · USEvotec (United States) · USTexas College · US

Funding

Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI EHRT, SABINE, GLICKMAN, MICHAEL S · 2014 to 2020
$48.6M
Vulnerabilities in Mycobacterial Cell-Wall BiogenesisP01AI095208 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SACCHETTINI, JAMES C · 2012 to 2022
$19.8M
Phase trafficking in combinatorial chemistry: ROM polymerizationP50GM069663 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI AUBE, JEFFREY · 2003 to 2012
$18.9M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Discovery of Phospopantetheinyl Transferse Inhibitors Against Mycobacterium tuberculosisR01AI155510 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AUBE, JEFFREY · 2021 to 2024
$3.1M
NIAID NIH HHS P01 AI095208NIAID NIH HHS R01 AI155510NIAID NIH HHS U19 AI111143NIGMS NIH HHS P41 GM103311NIGMS NIH HHS P50 GM069663
6 · The paper itself

Abstract

A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in

Indexed as

Bacterial ProteinsBinding SitesCrystallography, X-RayGuanidineKineticsMicrobial Sensitivity TestsMolecular ConformationMolecular Dynamics SimulationMycobacterium tuberculosisStructure-Activity RelationshipTransferases (Other Substituted Phosphate Groups)UreaBacterial ProteinsGuanidineguanidine carboxamidephosphopantetheinyl transferaseTransferases (Other Substituted Phosphate Groups)Urea

Identifiers

PMID35044775
PMCPMC8842310
OpenAlexW4205343986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.