Evidence map›Paper›PMID 35044710›Full record

ArticleChembiochem : a European journal of chemical biology2022

Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.

Tyler Eck, Mariana Laureano de Souza, Melvin Delvillar, Kutub Ashraf, Rammohan R Yadav Bheemanaboina, Ramappa Chakrasali, Tamara Kreiss, John J Siekierka, David P Rotella, Purnima Bhanot and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Tyler EckDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ 07043, USA.ORCID 0000-0003-2464-8138
Mariana Laureano de SouzaDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0000-0003-1886-3878
Melvin DelvillarDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.
Kutub AshrafDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0000-0003-2527-0085
Rammohan R Yadav BheemanaboinaDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ 07043, USA.
Ramappa ChakrasaliDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ 07043, USA.
Tamara KreissDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ 07043, USA.
John J SiekierkaDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ 07043, USA.
David P RotellaDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ 07043, USA.
Purnima BhanotDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.ORCID 0000-0001-5116-6973
Nina M GoodeyDepartment of Chemistry and Biochemistry, Montclair State University, Montclair, NJ 07043, USA.ORCID 0000-0001-8246-536X
Montclair State University · USRutgers, The State University of New Jersey · US

Funding

Development of inhibitors of P. falciparum cGMP dependent protein kinase (PfPKG) for malaria chemopreventionR01AI133633 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI BHANOT, PURNIMA, ROTELLA, DAVID · 2017 to 2019
$2.1M
NIAID NIH HHS R01 AI133633
6 · The paper itself

Abstract

Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) is an enticing antimalarial drug target. Novel chemotypes are needed because existing inhibitors have safety issues that may prevent further development. This work demonstrates isoxazole-based compounds are potent ATP competitive inhibitors of PfPKG and discloses a new analogue in this series. Isoxazoles 3 and 5 had K

Indexed as

AntimalarialsCyclic GMP-Dependent Protein KinasesPlasmodium falciparumProtein Kinase InhibitorsBinding SitesHumansProtein DomainsAntimalarialsCyclic GMP-Dependent Protein KinasesProtein Kinase Inhibitors

Identifiers

PMID35044710
PMCPMC9132199
OpenAlexW4206174597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.