Evidence map›Paper›PMID 35044651›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

PET Use in Cancer Diagnosis, Treatment, and Prognosis.

Naresh Damuka, Meghana Dodda, Kiran Kumar Solingapuram Sai

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Fluorinated Amphiphilic Dendrimer to Improve PET Imaging of Cancer.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Article
  3. Article
  4. [Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Naresh DamukaDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Meghana DoddaDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kiran Kumar Solingapuram SaiDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA. ksolinga@wakehealth.edu.

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Evaluating microtubule binding as a potential imaging biomarker for Alzheimer's diseaseR01AG065839 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOLINGAPURAM SAI, KIRAN · 2020 to 2024
$2.5M
NCI NIH HHS P30 CA012197NIA NIH HHS R01 AG065839
6 · The paper itself

Abstract

Tumorigenesis is a multistep process marked by variations in numerous metabolic pathways that affect cellular architectures and functions. Cancer cells reprogram their energy metabolism to enable several basic molecular functions, including membrane biosynthesis, receptor regulations, bioenergetics, and redox stress. In recent years, cancer diagnosis and treatment strategies have targeted these specific metabolic changes and the tumor's interactions with its microenvironment. Positron emission tomography (PET) captures all molecular alterations leading to abnormal function and cancer progression. As a result, the development of PET radiotracers increasingly focuses on irregular biological pathways or cells that overexpress receptors that have the potential to function as biomarkers for early diagnosis and treatment measurements as well as research. This chapter reviews both established and evolving PET radiotracers used to image tumor biology. We have also included a few advantages and disadvantages of the routinely used PET radiotracers in cancer imaging.

Indexed as

NeoplasmsPositron-Emission TomographyHumansMetabolic Networks and PathwaysRadiopharmaceuticalsTumor MicroenvironmentRadiopharmaceuticalsBiomarkersCancerMetabolismPositron emission tomographyRadiotracers

Identifiers

PMID35044651
PMCPMC9136679

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.