ArticleAnnals of biomedical engineering2022
Critical Pressure of Intramural Delamination in Aortic Dissection.
Article in Annals of biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Increased medial collagen enhances aortic resilience against mural delamination from hydraulic fracturing.bioRxiv : the preprint server for biology · 2026Article
- Aortic dissection as a disease of vascular wall homeostasis: integrating vasa vasorum-inflammation-metabolism axis for mechanistic insight and clinical translation.Frontiers in immunology · 2026Review
- Dissection Propagation via Avalanches in Human Descending Thoracic Aorta: Effect of Aging.Acta biomaterialia · 2025Article
- Retearing of type B blind cystic aortic dissection: computational fluid dynamics analysis.Physical and engineering sciences in medicine · 2025Article
- Association of sleep disturbance and sleep apnea with the size of the thoracic aorta and the main pulmonary artery.Scientific reports · 2025Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Mathematical modeling and numerical simulation of arterial dissection based on a novel surgeon's view.Biomechanics and modeling in mechanobiology · 2023Article
- Unraveling the Links between Chronic Inflammation, Autoimmunity, and Spontaneous Cervicocranial Arterial Dissection.Journal of clinical medicine · 2023Review
- Evolving Mural Defects, Dilatation, and Biomechanical Dysfunction in Angiotensin II-Induced Thoracic Aortopathies.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Simulating progressive intramural damage leading to aortic dissection using DeepONet: an operator-regression neural network.Journal of the Royal Society, Interface · 2022Article
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Authors and funding
3 authors.
Funding
Abstract
Computational models of aortic dissection can examine mechanisms by which this potentially lethal condition develops and propagates. We present results from phase-field finite element simulations that are motivated by a classical but seldom repeated experiment. Initial simulations agreed qualitatively and quantitatively with data, yet because of the complexity of the problem it was difficult to discern trends. Simplified analytical models were used to gain further insight. Together, simplified and phase-field models reveal power-law-based relationships between the pressure that initiates an intramural tear and key geometric and mechanical factors-insult surface area, wall stiffness, and tearing energy. The degree of axial stretch and luminal pressure similarly influence the pressure of tearing, which was ~88 kPa for healthy and diseased human aortas having sub-millimeter-sized initial insults, but lower for larger tear sizes. Finally, simulations show that the direction a tear propagates is influenced by focal regions of weakening or strengthening, which can drive the tear towards the lumen (dissection) or adventitia (rupture). Additional data on human aortas having different predisposing disease conditions will be needed to extend these results further, but the present findings show that physiologic pressures can propagate initial medial defects into delaminations that can serve as precursors to dissection.
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