ArticleTranslational vision science & technology2022
Lateral Resolution of a Commercial Optical Coherence Tomography Instrument.
Article in Translational vision science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Reflective broadband adaptive optics scanning light ophthalmoscope with 20 D focus range.Biomedical optics express · 2026Article
- Clinical and Imaging Characteristics of Thin and Thick Idiopathic Epiretinal Membranes Assessed by High-Resolution OCT.Investigative ophthalmology & visual science · 2026Article
- Real-Time High-Resolution OCT for Imaging Retinal and Choroidal Blood Flow.Investigative ophthalmology & visual science · 2026Article
- Synthetic X‑ray‑driven tracking and control of miniature medical devices.Nature machine intelligence · 2026Article
- Concentric macular rings and OCT corrugations in foveal hypoplasia: proof of concept for an optical interference mechanism.International journal of retina and vitreous · 2025Article
- Imaging of human airways by endoscope-compatible dynamic microscopic optical coherence tomography.Frontiers in medicine · 2025Article
- Biometry study of foveal isoplanatic patch variation for adaptive optics retinal imaging.Biomedical optics express · 2024Article
- Factors influencing the reliability of measurements in eyes with full-thickness macular holes: are we measuring incorrectly?BMJ open ophthalmology · 2024Observational
- Article
- Comparative analysis of changes in retinal layer thickness following femtosecond laser-assisted cataract surgery and conventional cataract surgery.BMC ophthalmology · 2024Article
- The sound of blood: photoacoustic imaging in blood analysis.Medicine in novel technology and devices · 2023Article
- Reliability of Retinal Layer Annotation with a Novel, High-Resolution Optical Coherence Tomography Device: A Comparative Study.Bioengineering (Basel, Switzerland) · 2023Article
- Spatio-temporal optical coherence tomography provides full thickness imaging of the chorioretinal complex.iScience · 2022Article
- Scanning laser ophthalmoscopy retroillumination: applications and illusions.International journal of retina and vitreous · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The lateral resolution of an optical coherence tomography (OCT) instrument was considered to be equal to the illumination spot size on the retina. To evaluate the potential lateral resolution of the Spectralis OCT, an instrument calculated to have a 14 µm resolution. Methods: The lateral point spread function (PSF) was evaluated using diamond abrasive powder 0 to 1 µm in diameter in silicone elastomer and a validated target with 800 nm FeO particles in urethane. The amplitude transfer function was calculated from human OCT images. Finally, resolution was measured using the 1951 USAF target. Results: Measurement of the lateral PSF from 1215 diamond particle images yielded a full-width half maximum (FWHM) to be 5.11 µm and for 732 FeO particles, 4.9 µm. From the amplitude transfer function, the FWHM of the diffraction limited PSF was calculated to be 5.0 µm. The USAF target imaging showed a lateral resolution of 4.6 µm. Conclusions: Although a calculation of the spot size of the illumination beam was reported in the past as the lateral resolution of the OCT instrument, the actual lateral resolution is better by a factor of at least 2.5 times. The clinically used A-scan spacing was derived from the calculated, and not the true resolution, and results in under sampling. This set of findings likely apply to all commercial clinical instruments. Translational Relevance: The scan density parameters of past and present commercial OCT instruments were based on earlier translational concepts, which now appear to have been incorrect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.