Evidence map›Paper›PMID 35044383›Full record

ArticleChemical communications (Cambridge, England)2022

Divinylpyrimidine reagents generate antibody-drug conjugates with excellent

Stephen J Walsh, Soleilmane Omarjee, Friederike M Dannheim, Dominique-Laurent Couturier, Dorentina Bexheti, Lee Mendil, Gemma Cronshaw, Toby Fewster, Charlotte Gregg, Cara Brodie and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Peroxide-cleavable linkers for antibody-drug conjugates.Chemical communications (Cambridge, England) · 2023
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Stephen J WalshYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. spring@ch.cam.ac.uk.ORCID http://orcid.org/0000-0002-3164-1519
Soleilmane OmarjeeCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.ORCID http://orcid.org/0000-0001-8686-7286
Friederike M DannheimYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. spring@ch.cam.ac.uk.ORCID http://orcid.org/0000-0003-4651-0850
Dominique-Laurent CouturierCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.ORCID http://orcid.org/0000-0001-5774-5036
Dorentina BexhetiCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.
Lee MendilCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.
Gemma CronshawCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.
Toby FewsterCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.
Charlotte GreggCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.
Cara BrodieCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.
Jodi L MillerCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.ORCID http://orcid.org/0000-0001-6870-204X
Richard HoughtonCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.
Jason S CarrollCancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK. Jason.carroll@cruk.cam.ac.uk.ORCID http://orcid.org/0000-0003-3643-0080
David R SpringYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. spring@ch.cam.ac.uk.ORCID http://orcid.org/0000-0001-7355-2824
University of Cambridge · GB

Funding

Cancer Research UK 20411
6 · The paper itself

Abstract

The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody-drug conjugates (ADCs) with

Indexed as

AnimalsAntineoplastic Agents, ImmunologicalCell Line, TumorHumansImmunoconjugatesIndicators and ReagentsMiceProof of Concept StudyPyrimidinesTrastuzumabXenograft Model Antitumor AssaysAntineoplastic Agents, ImmunologicalImmunoconjugatesIndicators and ReagentsPyrimidinesTrastuzumab

Identifiers

PMID35044383
PMCPMC9073851
OpenAlexW4206067139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.