Evidence map›Paper›PMID 35044332›Full record

ArticleCoronary artery disease2022

Patterns and outcomes of invasive management of type 2 myocardial infarction in the United States.

Nathaniel R Smilowitz, Binita Shah, Jeffrey Lorin, Jeffrey S Berger

Open access · greenAbstract read
In one paragraph

Article in Coronary artery disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nathaniel R SmilowitzLeon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine.
Binita ShahLeon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine.
Jeffrey LorinLeon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine.
Jeffrey S BergerLeon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine.
New York University · USVA NY Harbor Healthcare System · US

Funding

Mechanisms of Platelet Activity in Vascular DiseaseR35HL144993 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BERGER, JEFFREY S · 2019 to 2025
$5.5M
Platelet Activity and Vascular Health in Systemic Lupus ErythematosusR01HL139909 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BERGER, JEFFREY S, BUYON, JILL P · 2018 to 2022
$4.3M
Studies on the effects of colchicine on neutrophil biology in acute myocardial infarctionR01HL146206 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHAH, BINITA · 2019 to 2022
$2.4M
Mechanisms of Coronary Microvascular DiseaseK23HL150315 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMILOWITZ, NATHANIEL ROSSO · 2020 to 2024
$948k
Anti-inflammatory therapy during percutaneous coronary interventionIK2CX001074 · VA · VA MEDICAL CENTER · PI SHAH, BINITA · 2016 to 2021
–
CSRD VA IK2 CX001074NHLBI NIH HHS K23 HL150315NHLBI NIH HHS R01 HL139909NHLBI NIH HHS R01 HL146206NHLBI NIH HHS R35 HL144993
6 · The paper itself

Abstract

backgroundType 2 myocardial infarction (MI) occurs due to a mismatch in myocardial oxygen supply and demand without unstable coronary artery disease. We sought to identify patterns, predictors and outcomes of invasive management of type 2 MI in the USA.

methodsAdults aged ≥18 years hospitalized with type 2 MI were identified in a cross-sectional study from the 2018 National Inpatient Sample. Invasive management was defined as invasive coronary angiography or revascularization. Patient, hospital and geographic characteristics associated with invasive management were identified by multivariable logistic regression. Propensity-matched cohorts were generated to evaluate associations between invasive vs. conservative management and mortality.

resultsWe identified 268 850 admissions with type 2 MI in 2018. Type 2 MI patients had a high burden of comorbidities and were commonly admitted with diagnoses of circulatory (39.7%), infectious (23.1%) or respiratory (10.8%) illness. Only 11.2% of type 2 MI were managed invasively, of which 17.9% underwent coronary revascularization. Odds of invasive management were higher with commercial insurance [adjusted OR (aOR) 1.39; 95% confidence interval (CI), 1.27-1.52] and lower with Medicaid (aOR 0.86; 95% CI, 0.76-0.96) vs. Medicare. Significant heterogeneity in invasive management of type 2 MI was observed by geographic region (range 7.2-13.8%), independent of patient and hospital factors. Invasive management was associated with lower in-hospital mortality than conservative management overall (3.9 vs. 9.1%; P < 0.001) and in propensity-matched analyses (OR, 0.70; 95% CI, 0.59-0.84).

conclusionInvasive management of type 2 MI varies by insurance status and geography, highlighting uncertainty regarding optimal management and potential disparities in clinical care.

Indexed as

Anterior Wall Myocardial InfarctionMyocardial InfarctionPercutaneous Coronary InterventionAdolescentAdultAgedCoronary AngiographyCross-Sectional StudiesHumansMedicareTreatment OutcomeUnited States

Identifiers

PMID35044332
PMCPMC9064880
OpenAlexW4205536850

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.