Evidence map›Paper›PMID 35044218›Full record

ArticleMicrobiology spectrum2022

Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter baumannii in Critically Ill Patients.

Jiangang Zhang, Jinru Xie, Henan Li, Zhiren Wang, Yuyao Yin, Shuyi Wang, Hongbin Chen, Qi Wang, Hui Wang

Open access · goldAbstract readCase Reports
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Virulence · 2026
    Review
  2. Article
  3. Phenotypic and genetic heterogeneity ofMicrobial genomics · 2025
    Article
  4. Exploring the clinical outcomes and molecular characteristics ofFrontiers in cellular and infection microbiology · 2025
    Article
  5. Article
  6. Review
  7. Molecular epidemiology and resistance mechanisms of tigecycline-non-susceptible Acinetobacter baumannii isolated from a tertiary care hospital in Chongqing, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  8. The tigecycline resistance mechanisms in Gram-negative bacilli.Frontiers in cellular and infection microbiology · 2024
    Review
  9. Article
  10. Article
  11. Emergence and Evolution of OXA-23-Producing ST46Antibiotics (Basel, Switzerland) · 2023
    Article
  12. Resistance mechanisms of tigecycline inFrontiers in cellular and infection microbiology · 2023
    Review
  13. Fitness Costs of Tigecycline Resistance inAntibiotics (Basel, Switzerland) · 2022
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jiangang Zhang *Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Jinru Xie *Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Henan LiDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.ORCID 0000-0002-0872-704X
Zhiren WangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Yuyao YinDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Shuyi WangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Hongbin ChenDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Qi WangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Hui WangDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.ORCID 0000-0001-9220-0357
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acinetobacter baumannii is an important opportunistic pathogen of nosocomial infections. A. baumannii presently exhibits increasing antibiotic resistance, which poses great challenges to public health. The occurrence of tigecycline-resistant A. baumannii is related to tigecycline treatment and the within-host evolution of bacteria. We analyzed isogenic A. baumannii isolates from two critically ill patients who underwent tigecycline treatment. Whole-genome sequencing and comparative analyses were performed to determine the characteristics of genomic evolution. We conducted phenotypic studies, including

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnimalsAnti-Bacterial AgentsBacterial ProteinsCritical IllnessDrug Resistance, Multiple, BacterialGenome, BacterialGenomicsHumansMicrobial Sensitivity TestsMothsPhenotypePhylogenyTigecyclineVirulenceAnti-Bacterial AgentsBacterial ProteinsTigecyclineAcinetobacter baumanniitigecycline resistancevirulencewithin-host evolution

Identifiers

PMID35044218
PMCPMC8768575
OpenAlexW4205816117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.