Evidence map›Paper›PMID 35044105›Full record

ArticleJournal of cellular and molecular medicine2022

3,6'-disinapoyl sucrose attenuates Aβ

Xiaoli Tang, Yuming Zhao, Yanan Liu, Yang Liu, Yue Liu, Fenxi Niu, Fang Fang

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Saponin components inFrontiers in pharmacology · 2024
    Review
  7. Review
  8. Article
  9. 3,6'-disinapoyl sucrose attenuates AβJournal of cellular and molecular medicine · 2022
    Article
  10. Exendin-4 alleviates β-Amyloid peptide toxicityFrontiers in aging neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiaoli TangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Yuming ZhaoDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Yanan LiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.ORCID 0000-0003-3084-0898
Yang LiuState Key Lab for Structural Chemistry of Unstable and Stable Species, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.
Yue LiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Fenxi NiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Fang FangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Beijing University of Chinese Medicine · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aggregation of β-amyloid (Aβ) has the neurotoxicity, which is thought to play critical role in the pathogenesis of Alzheimer's disease (AD). Inhibiting Aβ deposition and neurotoxicity has been considered as an important strategy for AD treatment. 3,6'-Disinapoyl sucrose (DISS), one of the oligosaccharide esters derived from traditional Chinese medicine Polygalae Radix, possesses antioxidative activity, neuroprotective effect and anti-depressive activity. This study was to explore whether DISS could attenuate the pathological changes of Aβ

Indexed as

Alzheimer DiseaseCaenorhabditis elegansAmyloid beta-PeptidesAnimalsAntioxidantsAutophagyDisease Models, AnimalPeptide FragmentsSucroseAmyloid beta-Peptidesamyloid beta-protein (1-42)AntioxidantsPeptide FragmentsSucrose3,6'-disinapoyl sucroseAlzheimer's diseaseautophagyCaenorhabditis elegansoxidative stressβ-amyloid

Identifiers

PMID35044105
PMCPMC8831957
OpenAlexW4206451389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.