SynthesisCNS neuroscience & therapeutics2022
The need to be alert to complications of peri-lead cerebral edema caused by deep brain stimulation implantation: A systematic literature review and meta-analysis study.
Synthesis in CNS neuroscience & therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Severe immune rejection leading to refractory peri-electrode edema after DBS: a systematic review and one case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- The need to be alert to complications of peri-lead cerebral edema caused by deep brain stimulation implantation: A systematic literature review and meta-analysis study.CNS neuroscience & therapeutics · 2022Pooled it
- Incidental Finding of an Asymptomatic Perielectrode Cyst After Deep Brain Stimulation for Parkinson's Disease.Cureus · 2026Article
- Novel predictors of postoperative delirium after awake subthalamic nucleus deep brain stimulation for Parkinson's disease.BMJ neurology open · 2026Article
- Temporal Dynamics of Beta Power Related to the Stun Effect in Parkinson's Disease Patients after Deep Brain Stimulation Surgery.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Deep Brain Stimulation: Mechanisms, Cost-Effectiveness, and Precision Applications Across Neurology and Psychiatry.Biomedicines · 2025Review
- Multitarget neurostimulation of the deep brain: clinical opportunities, challenges, and emerging technologies.Journal of neural engineering · 2025Review
- Unveiling patterns of peri-lead edema after deep brain stimulation: a retrospective review of clinical and demographic factors.Neuroradiology · 2025Article
- An Unusual Presentation of Peri-Lead Edema Following Deep Brain Stimulation for Parkinson's Disease: A Case Report and Review of the Literature.Clinical case reports · 2025Article
- Imaging Findings of Intracerebral Infection after Deep Brain Stimulation: Pediatric Case Series and Literature Review.Movement disorders clinical practice · 2025Article
- Risk factors and significance of post-operative edema in Parkinson Disease patients submitted to deep brain stimulation. A ten-year case series.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Peri-lead edema in deep brain stimulation: common complication or rare challenge?Frontiers in surgery · 2025Article
- Deep Brain Stimulation Peri Lead Cyst Resolution with Nonoperative Management: Case Report and Review of the Literature.International medical case reports journal · 2025Article
- Vasogenic oedema during stereoelectroencephalography: intracranial pattern and late-onset clinical repercussion.Journal of neurology · 2024Article
- Postoperative use of steroids for peri-electrode edema after deep brain stimulation surgery: A retrospective cohort study.CNS neuroscience & therapeutics · 2024Article
- Surgical Complications in Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease: Experience in 800 Patients.Stereotactic and functional neurosurgery · 2024Article
- Which one is the superior target? A comparison and pooled analysis between posterior subthalamic area and ventral intermediate nucleus deep brain stimulation for essential tremor.CNS neuroscience & therapeutics · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe compatibility of deep brain stimulation (DBS) hardware and MRI scans has greatly improved the diagnostic rate of postoperative peri-lead edema (PLE). However, the etiology, incidence, and prognostic outcomes of this complication have not been established.
objectiveThe incidence of PLE and associated symptoms, the process of occurrence and progression of this complication, as well as treatment strategies were evaluated.
methodsWe conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses compliant systematic review of all studies that reported on incidences of PLE and associated symptoms after DBS implantation. Through systematic literature review, we evaluated its causes, neuropsychiatric symptoms, duration, treatment methods, and prognostic outcomes.
resultsOur search retrieved 10 articles, including 5 articles on PLE and 10 articles on symptomatic PLE. The incidence of PLE was 35.8% (95% CI: 17.0%-54.6%), while the incidence of symptomatic PLE was 3.1% (95% CI: 1.5%-4.7%) accounting for 8.7% of PLE.
conclusionsThis complication is not as rare as previously reported. Therefore, it requires significant attention after DBS implantation. The correlation between its causes, duration, symptoms, and the area involved in edema should be assessed in long-term prospective clinical studies with large sample sizes.
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