ArticleGenes, brain, and behavior2022
Heritability in corpus callosum morphology and its association with tool use skill in chimpanzees (Pan troglodytes): Reproducibility in two genetically isolated populations.
Article in Genes, brain, and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Corpus callosum microstructure in chimpanzees (pan troglodytes): associations with age, handedness and cognition.Frontiers in aging neuroscience · 2025Article
- Distributed genetic effects of the corpus callosum subregions suggest links to neuropsychiatric disorders and related traits.Acta neuropsychiatrica · 2023Article
- From fossils to mind.Communications biology · 2023Review
- Human and chimpanzee shared and divergent neurobiological systems for general and specific cognitive brain functions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Heritability in corpus callosum morphology and its association with tool use skill in chimpanzees (Pan troglodytes): Reproducibility in two genetically isolated populations.Genes, brain, and behavior · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
The corpus callosum (CC) is the major white matter tract connecting the left and right cerebral hemispheres. It has been hypothesized that individual variation in CC morphology is negatively associated with forebrain volume (FBV) and this accounts for variation in behavioral and brain asymmetries as well as sex differences. To test this hypothesis, CC surface area and thickness as well as FBV was quantified in 221 chimpanzees with known pedigrees. CC surface area, thickness and FBV were significantly heritable and phenotypically associated with each other; however, no significant genetic association was found between FBV, CC surface area and thickness. The CC surface area and thickness measures were also found to be significantly heritable in both chimpanzee cohorts as were phenotypic associations with variation in asymmetries in tool use skill, suggesting that these findings are reproducible. Finally, significant phenotypic and genetic associations were found between hand use skill and region-specific variation in CC surface area and thickness. These findings suggest that common genes may underlie individual differences in chimpanzee tool use skill and interhemispheric connectivity as manifest by variation in surface area and thickness within the anterior region of the CC.
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