Evidence map›Paper›PMID 35043830›Full record

ArticleSao Paulo medical journal = Revista paulista de medicina

Association between neck circumference and non-alcoholic fatty liver disease: cross-sectional analysis from ELSA-Brasil.

Laura Luiza Menezes Santos, Maria de Fátima Haueisen Sander Diniz, Alessandra Carvalho Goulart, Sandhi Maria Barreto, Roberta Carvalho Figueiredo

Abstract read
In one paragraph

Article in Sao Paulo medical journal = Revista paulista de medicina. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laura Luiza Menezes SantosMSc. Dietitian, Universidade Federal de São João Del-Rei (UFSJ), Divinópolis (MG), Brazil.ORCID http://orcid.org/0000-0002-5837-0309
Maria de Fátima Haueisen Sander DinizMD, PhD. Professor, Medical School and Clinical Hospital, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (MG), Brazil.ORCID http://orcid.org/0000-0001-9146-5003
Alessandra Carvalho GoulartMD, PhD. Clinical Epidemiologist and Researcher, Center of Clinical and Epidemiological Research, Hospital Universitário, Universidade de São Paulo (HU-USP), São Paulo (SP), Brazil.ORCID http://orcid.org/0000-0003-1076-5210
Sandhi Maria BarretoMD, PhD. Professor, Medical School and Clinical Hospital, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (MG), Brazil.ORCID http://orcid.org/0000-0001-7383-7811
Roberta Carvalho FigueiredoMD, PhD. Pharmacist and Professor, Universidade Federal de São João Del-Rei, Divinópolis (MG), Brazil.ORCID http://orcid.org/0000-0001-6462-3504

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-alcoholic fatty liver disease (NAFLD) has become a public health problem worldwide. Neck circumference (NC) is a simple anthropometric adiposity parameter that has been correlated with cardiometabolic disorders like NAFLD.

objectivesTo investigate the association between NC and NAFLD, considering their obesity-modifying effect, among participants from the Longitudinal Study of Adult Health (ELSA-Brasil) baseline study. DESIGN AND SETTINGS: Cross-sectional study at the ELSA-Brasil centers of six public research institutions.

methodsThis analysis was conducted on 5,187 women and 4,270 men of mean age 51.8 (± 9.2) years. Anthropometric indexes (NC, waist circumference [WC] and body mass index [BMI]), biochemical and clinical parameters (diabetes, hypertension and dyslipidemia) and hepatic ultrasound were measured. The association between NC and NAFLD was estimated using multinomial logistic regression, considering potential confounding effects (age, WC, diabetes, hypertension and dyslipidemia). Effect modification was investigated by including the interaction term NC x BMI in the final model.

resultsThe frequency of NAFLD and mean value of NC were 33.6% and 33.9 (± 2.5) cm in women, and 45.8% and 39.4 (± 2.8) cm in men, respectively. Even after all adjustments, larger NC was associated with a greater chance of moderate/severe NAFLD (1.16; 95% confidence interval [CI] for women; 1.05, 95% CI for men; P < 0.001). Presence of multiplicative interaction between NC and BMI (P < 0.001) was also observed.

conclusionNC was positively associated with NAFLD in both sexes, regardless of traditional adiposity indexes such as BMI and WC. The magnitude of the association was more pronounced among women.

Indexed as

Non-alcoholic Fatty Liver DiseaseAdultBody Mass IndexCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedNeckRisk FactorsWaist Circumference

Identifiers

PMID35043830
PMCPMC9610241

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.