Evidence map›Paper›PMID 35043823›Full record

ArticleJournal of materials chemistry. B2022

Enhanced photothermal heating and combination therapy of NIR dye

Samantha Macchi, Amanda Jalihal, Nasrin Hooshmand, Mohd Zubair, Samir Jenkins, Nabeel Alwan, Mostafa El-Sayed, Nawab Ali, Robert J Griffin, Noureen Siraj

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samantha MacchiDepartment of Chemistry, University of Arkansas at Little Rock, Little Rock, AR 72204, USA. nxsiraj@ualr.edu.ORCID 0000-0002-7546-4200
Amanda JalihalDepartment of Chemistry, University of Arkansas at Little Rock, Little Rock, AR 72204, USA. nxsiraj@ualr.edu.
Nasrin HooshmandLaser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA.
Mohd ZubairDepartment of Biology, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Samir JenkinsUniversity of Arkansas for Medical Sciences, Winthrop P. Rockefeller Cancer Institute, Arkansas Nanomedicine Center, Department of Radiation Oncology, 4301 W Markham St, Little Rock, AR 72205, USA.
Nabeel AlwanDepartment of Chemistry, University of Arkansas at Little Rock, Little Rock, AR 72204, USA. nxsiraj@ualr.edu.
Mostafa El-SayedLaser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA.
Nawab AliDepartment of Biology, University of Arkansas at Little Rock, Little Rock, AR 72204, USA.
Robert J GriffinUniversity of Arkansas for Medical Sciences, Winthrop P. Rockefeller Cancer Institute, Arkansas Nanomedicine Center, Department of Radiation Oncology, 4301 W Markham St, Little Rock, AR 72205, USA.
Noureen SirajDepartment of Chemistry, University of Arkansas at Little Rock, Little Rock, AR 72204, USA. nxsiraj@ualr.edu.ORCID 0000-0003-4925-0265

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
NIGMS NIH HHS P20 GM103429
6 · The paper itself

Abstract

Combination nanodrugs are promising therapeutic agents for cancer treatment. However, they often require the use of complex nanovehicles for transportation into the tumor site. Herein, a new class of carrier-free ionic nanomaterials (INMs) is presented, which are self-assembled by the drug molecules themselves. In this regard, a photothermal therapy (PTT) mechanism is combined with a chemotherapy (chemo) mechanism using ionic liquid chemistry to develop a combination drug to deliver multiple cytotoxic mechanisms simultaneously. Nanodrugs were developed from an ionic material-based chemo-PTT combination drug by using a simple reprecipitation method. Detailed examination of the photophysical properties (absorption, fluorescence emission, quantum yield, radiative and non-radiative rate) of the INMs revealed significant spectral changes which are directly related to their therapeutic effect. The reactive oxygen species quantum yield and the light to heat conversion efficiency of the photothermal agents were shown to be enhanced in combination nanomedicines as compared to their respective parent compounds. The ionic nanodrugs exhibited an improved dark and light cytotoxicity

Indexed as

NanoparticlesPhototherapyCombined Modality TherapyDrug Delivery SystemsHot TemperatureIonsIons

Identifiers

PMID35043823
PMCPMC8928910

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.