Evidence map›Paper›PMID 35043685›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022

A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous

Kenjiro Shima, Paritha Arumugam, Anthony Sallese, Yuko Horio, Yan Ma, Cole Trapnell, Matthew Wessendarp, Claudia Chalk, Cormac McCarthy, Brenna C Carey and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Pathogenesis-driven treatment of primary pulmonary alveolar proteinosis.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  5. A toxicology study ofMolecular therapy. Methods & clinical development · 2024
    Article
  6. Molecular therapy. Methods & clinical development · 2024
    Article
  7. Autoimmune Pulmonary Alveolar Proteinosis.American journal of respiratory and critical care medicine · 2022
    Article
  8. Frontiers in immunology · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Kenjiro ShimaTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Paritha ArumugamTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Anthony SalleseTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Yuko HorioTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Yan MaTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Cole TrapnellDepartment of Genome Sciences, University of Washington, Seattle, Washington.
Matthew WessendarpTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Claudia ChalkTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Cormac McCarthyTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Brenna C CareyTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0002-2915-4754
Bruce C TrapnellTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0003-2817-6254
Takuji SuzukiTranslational Pulmonary Science Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Cincinnati Children's Hospital Medical Center · USUniversity of Washington · US

Funding

Role of GM-CSF in Myeloid Cell Function and Innate ImmunityR01HL085453 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C · 2007 to 2023
$6.5M
Pulmonary Macrophage Transplantation for Pulmonary Alveolar ProteinosisR01HL118342 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C, TRAPNELL, BRUCE COLSTON · 2014 to 2021
$4.5M
Genome edited iPS cell-derived macrophages as a novel lung cell therapyR01HL136721 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SUZUKI, TAKUJI · 2017 to 2020
$1.6M
Human gene transfer & macrophage cell transplantation therapy of hereditary PAP (hPAP)R61HL156888 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KRISCHER, JEFFREY P, TRAPNELL, BRUCE C · 2021 to 2022
$800k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIH R01 HL118342HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIH R01 HL136721MEXT | Japan Society for the Promotion of Science (JSPS) Kakenhi 16K21750NHLBI NIH HHS R01 HL085453NHLBI NIH HHS R01 HL118342NHLBI NIH HHS R01 HL136721NHLBI NIH HHS R61 HL156888
6 · The paper itself

Abstract

Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder caused by recessive mutations in GM-CSF receptor subunit α/β genes (

Indexed as

Pulmonary Alveolar ProteinosisPulmonary SurfactantsAnimalsDisease Models, AnimalGranulocyte-Macrophage Colony-Stimulating FactorHumansMacrophages, AlveolarMiceReceptors, Granulocyte-Macrophage Colony-Stimulating FactorSurface-Active AgentsCSF2RA protein, humanCsf2ra protein, mouseGranulocyte-Macrophage Colony-Stimulating FactorPulmonary SurfactantsReceptors, Granulocyte-Macrophage Colony-Stimulating FactorSurface-Active Agentsalveolar macrophageGM-CSF receptorhereditary pulmonary alveolar proteinosissurfactant homeostasis

Identifiers

PMID35043685
PMCPMC8917935
OpenAlexW4205849969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.