Evidence map›Paper›PMID 35043661›Full record

ArticleJournal of the American Heart Association2022

Perivascular Adipose Tissue Is a Major Source of Nitric Oxide in Saphenous Vein Grafts Harvested via the No-Touch Technique.

Toshiro Saito, Hiroshi Kurazumi, Ryo Suzuki, Kazumasa Matsunaga, Sarii Tsubone, Bochao Lv, Sei Kobayashi, Takashi Nagase, Takahiro Mizoguchi, Makoto Samura and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Role of Perivascular Adipose Tissue in Vein Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
  4. Article
  5. Review
  6. The Role of Advanced Glycation End Products in Saphenous Vein Graft Failure.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
    Article
  7. Review
  8. The Clinical Utility of No-Touch Saphenous Vein Grafting as a Second Conduit in Multivessel Coronary Artery Bypass Surgery.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2025
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Endoscopic Pedicle Saphenous Vein Graft Harvesting.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Toshiro SaitoDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.ORCID 0000-0003-0845-9265
Hiroshi KurazumiDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.ORCID 0000-0002-4009-7391
Ryo SuzukiDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.ORCID 0000-0002-5465-5948
Kazumasa MatsunagaDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.ORCID 0000-0001-9474-6898
Sarii TsuboneDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.
Bochao LvDepartment of Molecular and Cellular Physiology Yamaguchi University Graduate School of Medicine Yamaguchi Japan.
Sei KobayashiDepartment of Molecular and Cellular Physiology Yamaguchi University Graduate School of Medicine Yamaguchi Japan.
Takashi NagaseDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.
Takahiro MizoguchiDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.
Makoto SamuraDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.
Kotaro SuehiroDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.
Takasuke HaradaDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.
Noriyasu MorikageDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.
Akihito MikamoDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.
Kimikazu HamanoDepartment of Surgery and Clinical Science Yamaguchi University Graduate School of Medicine Yamaguchi Japan.ORCID 0000-0003-3455-7248
Yamaguchi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Saphenous vein grafts (SVGs) are broadly used in coronary artery bypass grafting despite their inferior patency compared with arterial grafts. Recently, the no-touch technique (NT), in which an SVG is harvested with a pedicle of perivascular adipose tissue (PVAT) without conduit distension, was shown to improve long-term patency compared with conventional preparation (CV), wherein outer tissue is removed with distension. The NT was also reportedly associated with reduced atherosclerosis. Although endothelial damage provoked by conventional distension may underlie poor patency when CV is performed, the precise mechanisms underlying the salutary effects of the NT have been unclear. Methods and Results Residual SVGs prepared with CV (CV-SVGs) or NT (NT-SVGs) were obtained during coronary artery bypass grafting. Nitric oxide (NO

Indexed as

AtherosclerosisSaphenous VeinAdipose TissueDilatation, PathologicHumansNitric OxideVascular PatencyNitric Oxideconventional preparationcoronary artery bypass graftingnitric oxideno‐touch techniquesaphenous vein graft

Identifiers

PMID35043661
PMCPMC9238502
OpenAlexW4206533587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.