Evidence map›Paper›PMID 35043355›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Do neuropsychiatric fluctuations temporally match motor fluctuations in Parkinson's disease?

Eleonora Del Prete, Emmanuelle Schmitt, Sara Meoni, Valerie Fraix, Anna Castrioto, Pierre Pelissier, Roberto Ceravolo, Elena Moro

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Eleonora Del PreteMovement Disorders Unit, Division of Neurology, CHU of Grenoble, Boulevard de la Chantourne La Tronche, 38043, Grenoble, France.
Emmanuelle SchmittMovement Disorders Unit, Division of Neurology, CHU of Grenoble, Boulevard de la Chantourne La Tronche, 38043, Grenoble, France.
Sara MeoniMovement Disorders Unit, Division of Neurology, CHU of Grenoble, Boulevard de la Chantourne La Tronche, 38043, Grenoble, France.
Valerie FraixMovement Disorders Unit, Division of Neurology, CHU of Grenoble, Boulevard de la Chantourne La Tronche, 38043, Grenoble, France.
Anna CastriotoMovement Disorders Unit, Division of Neurology, CHU of Grenoble, Boulevard de la Chantourne La Tronche, 38043, Grenoble, France.
Pierre PelissierMovement Disorders Unit, Division of Neurology, CHU of Grenoble, Boulevard de la Chantourne La Tronche, 38043, Grenoble, France.
Roberto CeravoloDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
Elena MoroMovement Disorders Unit, Division of Neurology, CHU of Grenoble, Boulevard de la Chantourne La Tronche, 38043, Grenoble, France. emoro@chu-grenoble.fr.ORCID http://orcid.org/0000-0002-7968-5908
Inserm · FRCentre Hospitalier Universitaire de Grenoble · FRUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn Parkinson's disease (PD), non-motor fluctuations (NMFs), especially neuropsychiatric fluctuations, often coexist with motor fluctuations (MFs) but are often under-recognized by physicians and patients.

objectiveTo investigate the relationship between MFs and neuropsychiatric fluctuations in PD.

methodsPD patients with MFs and NMFs were enrolled. The Parkinson's Kinetigraph (PKG), a wearable device to detect MFs and dyskinesia, was used to confirm and measure MFs. The Neuropsychiatric Fluctuation Scale (NFS), a scale composed by subscores for both the ON and OFF neuropsychiatric states, was used to identify and quantify neuropsychiatric fluctuations. Patients were asked to wear the PKG for six consecutive days to identify the ON and OFF motor periods, and then to fill the NFS during the ON and OFF motor periods for three consecutive days wearing the PKG. The PKG system provided a bradykinesia score (BKS) and a dyskinesia score (DKS). Relations between BKS, DKS, and ON and OFF NFS subscores were analyzed.

resultsIn 18 PD patients, anxiety, apathy, and depression characterized the OFF condition, whereas self-confidence, competency, and interest in doing things were typically in the ON condition. There was a positive correlation between the BKS and the OFF NFS subscores (p = 0.036, r = 0.51), whereas no correlation was found between the DKS and the ON NFS subscores (p = 0.38, r = 0.22).

conclusionNeuropsychiatric fluctuations temporarily matched the OFF MFs only in the OFF condition. These findings are useful to better manage OFF NMSs and support the need to further investigate associations between non-motor and motor symptoms in PD patients.

Indexed as

DyskinesiasParkinson DiseaseAnxiety DisordersHumansHypokinesiaDyskinesiaMotor fluctuationsNon-motor fluctuationsParkinson’s disease

Identifiers

PMID35043355
OpenAlexW4205237267

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.