Evidence map›Paper›PMID 35043291›Full record

ArticleEuropean radiology2022

Statin use and MRI subchondral bone marrow lesion worsening in generalized osteoarthritis: longitudinal analysis from Osteoarthritis Initiative data.

Bahram Mohajer, Ali Guermazi, Philip G Conaghan, Francis Berenbaum, Frank W Roemer, Arya Haj-Mirzaian, Clifton O Bingham, Kamyar Moradi, Xu Cao, Mei Wan and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Review
  6. Review
  7. Latest advancements in imaging techniques in OA.Therapeutic advances in musculoskeletal disease · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 5 countries.

Bahram MohajerMusculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ali GuermaziDepartment of Radiology, Boston University School of Medicine, Boston, MA, USA.
Philip G ConaghanLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, UK.
Francis BerenbaumDepartment of Rheumatology, Sorbonne University, INSERM CRSA, AP-HP Hospital Saint Antoine, Paris, France.
Frank W RoemerDepartment of Radiology, Boston University School of Medicine, Boston, MA, USA.
Arya Haj-MirzaianMusculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Clifton O BinghamDivision of Rheumatology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Kamyar MoradiStudents Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Xu CaoDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mei WanDepartment of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shadpour DemehriMusculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. demehri2001@yahoo.com.
Johns Hopkins Medicine · USJohns Hopkins University · USBoston University · USCentre de Recherche Saint-Antoine · FRFriedrich-Alexander-Universität Erlangen-Nürnberg · DETehran University of Medical Sciences · IRUniversity of Leeds · GB

Funding

Skeleton and Joint Degeneration with AgingP01AG066603 · NIA · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2021 to 2025
$9.2M
Effect of statin intake on Non-traumatic Generalized Knee OsteoarthritisR01AR079620 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI DEMEHRI, SHADPOUR · 2021 to 2025
$1.8M
NIAMS NIH HHS R01 AR079620NIAMS NIH HHS R01AR079620-01NIA NIH HHS P01 AG066603NIA NIH HHS P01AG066603
6 · The paper itself

Abstract

objectivesTo determine the association between statin therapy and knee MRI-detected subchondral bone marrow lesion (BML) longitudinal worsening in patients with Heberden's nodes (HNs) as the hallmark of generalized osteoarthritis (OA) phenotype.

methodsAll participants gave informed consent, and IRB approved HIPAA-compliant protocol. We assessed the worsening in BML volume and number of affected subregions in the Osteoarthritis Initiative (OAI) participants with HNs at baseline clinical examination (HN

resultsThe PS-matched HN

conclusionIn patients with CVD indications for statin therapy and generalized OA phenotype (HN KEY POINTS: • Statin use may reduce the risk of subchondral bone damage in specific osteoarthritis patients with a generalized phenotype, minimal subchondral bone damage, and cardiovascular statin indications.

Indexed as

Cardiovascular DiseasesCartilage DiseasesHydroxymethylglutaryl-CoA Reductase InhibitorsOsteoarthritis, KneeBone MarrowDisease ProgressionFemaleHumansKnee JointMagnetic Resonance ImagingMaleHydroxymethylglutaryl-CoA Reductase InhibitorsBone marrowHydroxymethylglutaryl-CoA reductase inhibitorsKneeMagnetic resonance imagingOsteoarthritis

Identifiers

PMID35043291
PMCPMC9583891
OpenAlexW4205823860

What OpenQuestion holds

Texttitle and abstract
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.