SynthesisArchives of orthopaedic and trauma surgery2023
The use of platelet-rich plasma in studies with early knee osteoarthritis versus advanced stages of the disease: a systematic review and meta-analysis of 31 randomized clinical trials.
Synthesis in Archives of orthopaedic and trauma surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Efficacy and safety of platelet-rich plasma injections for the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.European journal of medical research · 2025Pooled it
- Platelet rich plasma injections for knee osteoarthritis: an overview of systematic reviews.Frontiers in physiology · 2025Pooled it
- Comparison of the clinical effectiveness of activated and non-activated platelet-rich plasma in the treatment of knee osteoarthritis: a systematic review and meta-analysis.Clinical rheumatology · 2023Pooled it
- Mesenchymal stem cells and platelet rich plasma therapy for knee osteoarthritis: an umbrella review of systematic reviews with meta-analysis.Annals of Saudi medicinePooled it
- A Brief Overview and Update of Regenerative Medicine for the Treatment of Musculoskeletal Conditions.Current reviews in musculoskeletal medicine · 2026Review
- Managing Osteoarthritis Pain in Underrepresented Populations: Insights from Mexico and Latin America.Journal of clinical medicine · 2026Review
- Histological effects of intra-articular allogeneic leukocyte-rich and leukocyte-poor platelet-rich plasma in healthy rabbit knees: an exploratory study.BMC research notes · 2026Article
- Spin and reporting bias in the use of platelet-rich plasma for the treatment of knee osteoarthritis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Review
- Current Perspectives on Platelet-Rich Plasma Injections for Knee Osteoarthritis: How to Optimize Clinical Outcomes.Open access journal of sports medicine · 2025Review
- Advanced Non-Operative Interventions for Anterior Knee Pain.Current reviews in musculoskeletal medicine · 2024Review
- Platelet-Rich Plasma for Knee and Hip Osteoarthritis Pain: A Scoping Review.Current reviews in musculoskeletal medicine · 2024Article
- Time to Total Knee Arthroplasty (TKA) Post Intra-Articular Injection.Journal of clinical medicine · 2024Article
- Long term improvement of knee osteoarthritis after injection of single high/very high volume of very pure PRP: A retrospective analysis of patients optimally managed in dedicated centers.Regenerative therapy · 2024Article
- Platelet-Rich Plasma for Knee Osteoarthritis: What Does the Evidence Say?Drugs & aging · 2023Review
- Preparation and Utility of Platelet-Rich Plasma (PRP) for Facial Aging: A Comprehensive Review.Advances in therapy · 2022Review
- Swiss Medical Devices for Autologous Regenerative Medicine: From Innovation to Clinical Validation.Pharmaceutics · 2022Review
- Chondroprotective Effects of 4,5-Dicaffeoylquinic Acid in Osteoarthritis through NF-κB Signaling Inhibition.Antioxidants (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionReports have concluded that platelet-rich plasma (PRP) is an effective and safe biological approach to treating knee osteoarthritis (OA). However, the effectiveness of PRP in advanced stages of the disease is not entirely clear. The purpose of this study was to evaluate whether the use of PRP would be as effective in studies with early-moderate knee OA patients compared to studies including patients with end-stage OA, based on the Kellgren-Lawrence classification. MATERIALS AND
methodsA comprehensive search in MEDLINE, EMBASE, Scopus, and Web of Science databases was conducted to identify randomized controlled trials (RCTs) comparing the effect of PRP injections versus other intra-articular treatments on pain and functionality. A meta-analysis was conducted using a random-effects model and the generic inverse variance method.
resultsWe included 31 clinical trials that reported data of 2705 subjects. Meta-analysis revealed an overall significant improvement of both pain [MD, - 1.05 (95% CI - 1.41 to - 0.68); I
conclusionOur results indicate that including patients with advanced knee OA does not seem to affect the outcomes of clinical trials in which the effectiveness of the PRP in knee OA is assessed.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.